Entry Detail

General Information

Database ID: LDA0000588
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FOXD2-AS1
Full Name:FOXD2 adjacent opposite strand RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):47432133End Site(bp):47434641
External Links:
Ensembl ID:ENSG00000237424
Ensembl Transcript ID:N/A
Entrez Gene:84793.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:42   
More Information
Causal Disease Number:38
Network:
Top Causal Diseases:
Glioma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Glioma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Breast Neoplasms  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2600
Disease Name:laryngeal carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A larynx cancer that has_material_basis_in epithelial cells.
Alias:cancer of larynx//carcinoma of larynx

 

Disease Association Statistics

Total Associated ncRNA Number:22   
More Information
Causal ncRNA Number:18
Network:
Top Causal ncRNAs:
FOXD2-AS1  (Score: 0.731059)
WTAPP1  (Score: 0.731059)
SNHG3  (Score: 0.731059)
circABCB10  (Score: 0.731059)
CASC9  (Score: 0.731059)
AFAP1-AS1  (Score: 0.731059)
LINC01303  (Score: 0.731059)
LINC00886  (Score: 0.731059)
MALAT1  (Score: 0.731059)
FOXD2-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31163553
Disease Name:laryngeal carcinoma
Sample:laryngeal cancer tissues
Dysfunction Pattern:Interaction[targeting miR-206]
Validated Method:qRT-PCR//Luciferase Report Assay//MTT//Colony Formation Assay
Description:: The expression of FOXD2-AS1 in laryngeal cancer tissues was significantly higher than that in normal tissues(t=10.012, P<0.05), and was associated with T staging of laryngeal cancer(χ=6.41, P=0.016). Double luciferase assay showed that FOXD2-AS1 could directly bind to miR-206, thus inhibiting the expression of miR-206. Further MTT assay indicated that inhibiting miR-206 attenuated the suppressing effect of si-FOXD2-AS1 on the proliferation of TU686 cells.
Causality:Yes
Causal Description:FOXD2-AS1 down regulated proliferation activity of TU686 cells(t=9.337, P<0.05).
Clinical-realted Application:The expression of FOXD2-AS1 in laryngeal cancer tissues was significantly higher than that in normal tissues(t=10.012, P<0.05), and was associated with T staging of laryngeal cancer(χ=6.41, P=0.016).