Entry Detail

General Information

Database ID: LDA0000589
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FOXD2-AS1
Full Name:FOXD2 adjacent opposite strand RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):47432133End Site(bp):47434641
External Links:
Ensembl ID:ENSG00000237424
Ensembl Transcript ID:N/A
Entrez Gene:84793.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:42   
More Information
Causal Disease Number:38
Network:
Top Causal Diseases:
Glioma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Glioma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Breast Neoplasms  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8923
Disease Name:skin melanoma
Category:Disease Ontology
Type:Neoplasms
Define:A skin cancer that has_material_basis_in melanocytes.
Alias:cutaneous melanoma//malignant ear melanoma//malignant lip melanoma//malignant lower limb melanoma//malignant melanoma of ear and/or external auricular canal//malignant melanoma of skin of lower limb//malignant melanoma of skin of trunk except scrotum//malignant melanoma of skin of upper limb//malignant neck melanoma//malignant scalp melanoma//malignant trunk melanoma//malignant upper limb melanoma

 

Disease Association Statistics

Total Associated ncRNA Number:10   
More Information
Causal ncRNA Number:10
Network:
Top Causal ncRNAs:
HOXA11-AS  (Score: 0.731059)
HCP5  (Score: 0.731059)
HSD11B1-AS1  (Score: 0.731059)
FOXD2-AS1  (Score: 0.731059)
FOXD3-AS1  (Score: 0.731059)
HOXA11-AS  (Score: 0.731059)
HCP5  (Score: 0.731059)
HSD11B1-AS1  (Score: 0.731059)
FOXD2-AS1  (Score: 0.731059)
FOXD3-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Transwell Assay//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:30426532
Disease Name:skin melanoma
Sample:cutaneous melanoma tissues
Dysfunction Pattern:Interaction[phospho-Akt ]
Validated Method:CCK8//qRT-PCR//Western Blot//Transwell Assay
Description:In our study, FOXD2-AS1 expression has been found to be Expression[Expression[up-expression]-expression]regulated in cutaneous melanoma tissue specimens and cell lines compared with that in normal tissue specimens and normal human epidermal melanocyte, respectively.
Causality:Yes
Causal Description:The results of loss-of-function study showed that inhibition of FOXD2-AS1 sExpression[Expression[up-expression]-expression]presses cutaneous melanoma cell proliferation, migration and invasion through regulating phospho-Akt expression.
Clinical-realted Application:Furthermore, high expression of FOXD2-AS1 was obviously correlated with deep Breslow thickness, present ulceration, high Clark level and distant metastasis in cutaneous melanoma patients.