Entry Detail

General Information

Database ID: LDA0000591
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FOXD2-AS1
Full Name:FOXD2 adjacent opposite strand RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):47432133End Site(bp):47434641
External Links:
Ensembl ID:ENSG00000237424
Ensembl Transcript ID:N/A
Entrez Gene:84793.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:42   
More Information
Causal Disease Number:38
Network:
Top Causal Diseases:
Glioma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Glioma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Breast Neoplasms  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0002116D011625
Disease Name:pterygiumPterygium
Category:Disease OntologyMeSH
Type:Eye Diseases
Define:A corneal disease that is characterized by a triangular tissue growth located_in cornea of the eye that is the result of collagen degeneration and fibrovascular proliferation.An abnormal triangular fold of membrane in the interpalpebral fissure, extending from the conjunctiva to the cornea, being immovably united to the cornea at its apex, firmly attached to the sclera throughout its middle portion, and merged with the conjunctiva at its base. (Dorland, 27th ed)
Alias:surfer's eyePterygium//Pterygiums

 

Disease Association Statistics

Total Associated ncRNA Number:596   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
FOXD2-AS1  (Score: 0.731059)
FAM88C  (Score: 0.731059)
FOXD2-AS1  (Score: 0.731059)
FAM88C  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Flow Cytometry//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:33098266
Disease Name:Pterygium
Sample:recurrent pterygium tissues
Dysfunction Pattern:interaction[sponging miR-205-5p]
Validated Method:CCK8//qRT-PCR//Flow Cytometry//ChIP
Description: FOXD2-AS1 expression was up-regulated in recurrent pterygium tissues. In conclusion, FOXD2-AS1 is activated via its H3K27 acetylation and regulates VEGF-A expression by sponging miR-205-5p in recurrent pterygium.
Causality:Yes
Causal Description: Furthermore, we show that FOXD2-AS1 induced proliferation and inhibited apoptosis in a cell line derived from recurrent pterygia (HPF-R) at least partially through the regulation of the miR-205-VEGF pathway.
Clinical-realted Application:Moreover, a high FOXD2-AS1 expression was associated with advanced stages, increased microvessel density and shorter recurrent-free survival.