Entry Detail

General Information

Database ID: LDA0000598
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FLVCR1-DT
Full Name:FLVCR1 divergent transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:FLVCR1-AS1|LQK1|NCRNA00292
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):212856604End Site(bp):212858138
External Links:
Ensembl ID:ENSG00000198468
Ensembl Transcript ID:N/A
Entrez Gene:642946.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:22   
More Information
Causal Disease Number:20
Network:
Top Causal Diseases:
Uterine Cervical Neoplasms  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.731059)
Cholangiocarcinoma  (Score: 0.731059)
Pancreatic Neoplasms  (Score: 0.731059)
Glioma  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Lung Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4928D018281
Disease Name:intrahepatic cholangiocarcinomaCholangiocarcinoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A cholangiocarcinoma that arises from the intrahepatic bile duct epithelium in any site of the intrahepatic biliary tree.A malignant tumor arising from the epithelium of the BILE DUCTS.
Alias:Intrahepatic bile duct carcinoma//peripheral CholangiocarcinomaCholangiocarcinoma//Cholangiocarcinomas//Cholangiocellular Carcinoma//Carcinoma, Cholangiocellular//Carcinomas, Cholangiocellular//Cholangiocellular Carcinomas//Extrahepatic Cholangiocarcinoma//Cholangiocarcinoma, Extrahepatic//Cholangiocarcinomas, Extrahepatic//Extrahepatic Cholangiocarcinomas//Intrahepatic Cholangiocarcinoma//Cholangiocarcinoma, Intrahepatic//Cholangiocarcinomas, Intrahepatic//Intrahepatic Cholangiocarcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:164   
More Information
Causal ncRNA Number:144
Network:
Top Causal ncRNAs:
NNT-AS1  (Score: 0.999893)
NNT-AS1  (Score: 0.999893)
SNHG3  (Score: 0.985791)
MEG3  (Score: 0.985791)
NEAT1  (Score: 0.985791)
TTN-AS1  (Score: 0.985791)
SNHG1  (Score: 0.985791)
AGAP2-AS1  (Score: 0.985791)
CASC2  (Score: 0.985791)
PVT1  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31404302
Disease Name:Cholangiocarcinoma
Sample:CCA tumor tissues
Dysfunction Pattern:Interaction[sponging miR-485-5p]
Validated Method:Western Blot//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay
Description:A significantly higher expression level of FLVCR1-AS1 was identified in CCA tumor tissues and the CCA cell lines HuCCT1 and CCLP1 compared with the normal controls. Mechanistically, FLVCR1-AS1 was demonstrated to sponge microRNA-485-5p (miR-485-5p) in human CCA. The expression of miR-458-5p was significantly decreased in CCA tissue compared with normal tissue, and Pearson's correlation analysis revealed that FLVCR1-AS1 expression was negatively correlated with miR-485-5p expression in CCA tissues.
Causality:Yes
Causal Description:Furthermore, FLVCR1-AS1 knockdown inhibited tumor growth in a xenograft model.
Clinical-realted Application: