Entry Detail

General Information

Database ID: LDA0000611
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FGD5-AS1
Full Name:FGD5 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:3
Strand:-
Coordinate:
Start Site(bp):14942779End Site(bp):14948441
External Links:
Ensembl ID:ENSG00000225733
Ensembl Transcript ID:N/A
Entrez Gene:100505641.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:36   
More Information
Causal Disease Number:30
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Mouth Neoplasms  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Mouth Neoplasms  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D010020
Disease Name:Osteonecrosis
Category:MeSH
Type:Musculoskeletal Diseases
Define:Death of a bone or part of a bone, either atraumatic or posttraumatic.
Alias:Osteonecrosis//Osteonecroses//Bone Necrosis//Bone Necroses//Necroses, Bone//Necrosis, Bone//Necrosis, Avascular, of Bone//Avascular Necrosis of Bone//Bone Avascular Necrosis//Kienbock Disease//Kienbock's Disease//Kienboeck Disease//Kienboeck's Disease//Kienboecks Disease//Necrosis, Aseptic, of Bone//Aseptic Necrosis of Bone//Bone Aseptic Necrosis

 

Disease Association Statistics

Total Associated ncRNA Number:6   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
FGD5-AS1  (Score: 0.731059)
NORAD  (Score: 0.731059)
FGD5-AS1  (Score: 0.731059)
NORAD  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35190765
Disease Name:Osteonecrosis
Sample:hBMSCs
Dysfunction Pattern:Interaction(miR-296-5p/STAT3 Axis)
Validated Method:Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay
Description: In addition, lncRNA FGD5-AS1 acts as a sponge for miR-296-5p. Also, miR-296-5p directly targets STAT3. More importantly, miR-296-5p and STAT3 can affect the function of lncRNA FGD5-AS1 in Dex-treated hBMSCs.
Causality:Yes
Causal Description:Overexpression of lncRNA FGD5-AS1 promoted cell proliferation and restrained apoptosis in Dex-treated hBMSCs.
Clinical-realted Application: