Entry Detail

General Information

Database ID: LDA0000622
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FIRRE
Full Name:firre intergenic repeating RNA element
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC01200
Chromosome:X
Strand:-
Coordinate:
Start Site(bp):131691525End Site(bp):131830643
External Links:
Ensembl ID:ENSG00000213468
Ensembl Transcript ID:N/A
Entrez Gene:286467.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:8   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 0.985791)
Lymphoma, Large B-Cell, Diffuse  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Lymphoma, Large B-Cell, Diffuse  (Score: 0.985791)
Gallbladder Neoplasms  (Score: 0.731059)
Gallbladder Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3121D005706
Disease Name:gallbladder cancerGallbladder Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A biliary tract cancer that is located_in the gallbladder.Tumors or cancer of the gallbladder.
Alias:gallbladder Ca//gallbladder neoplasm//localized malignant gallbladder neoplasm//malignant neoplasm of gallbladder//malignant tumor of the gallbladder//malignant tumour of gallbladder//tumor of the gallbladderGallbladder Neoplasms//Gallbladder Neoplasm//Neoplasm, Gallbladder//Neoplasms, Gallbladder//Cancer of Gallbladder//Gallbladder Cancers//Gallbladder Cancer//Cancer, Gallbladder//Cancers, Gallbladder//Gall Bladder Cancer//Bladder Cancer, Gall//Bladder Cancers, Gall//Cancer, Gall Bladder//Cancers, Gall Bladder//Gall Bladder Cancers//Cancer of the Gallbladder

 

Disease Association Statistics

Total Associated ncRNA Number:52   
More Information
Causal ncRNA Number:38
Network:
Top Causal ncRNAs:
PVT1  (Score: 0.999893)
PVT1  (Score: 0.999893)
MEG3  (Score: 0.985791)
MEG3  (Score: 0.985791)
LINC01410  (Score: 0.731059)
FOXD2-AS1  (Score: 0.731059)
RP11-147L13.8  (Score: 0.731059)
HOXA-AS2  (Score: 0.731059)
EPIC1  (Score: 0.731059)
FIRRE  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//RIP//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay//IHC//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34168678
Disease Name:Gallbladder Neoplasms
Sample:60 GBC and 20 para-carcinoma tissue samples
Dysfunction Pattern:Interaction(miR-520a-3p/YOD1)
Validated Method:In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//RIP//Luciferase Report Assay//Cell Proliferation Assay//Cell Cycle Assay//IHC//Transwell Assay
Description:FIRRE level was dramatically increased in GBC tissues compared to that in the adjacent non-tumor tissues. Mechanistically, FIRRE modulated YOD1 expression by sponging miR-520a-3p, thus contributing to the development of GBC.
Causality:Yes
Causal Description:Moreover, FIRRE remarkably enhanced proliferation and migration, and inhibited apoptosis of GBC cells.
Clinical-realted Application:High expression of FIRRE was closely related to clinical stage and poor prognosis in GBC patients.