Entry Detail

General Information

Database ID: LDA0000623
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FIRRE
Full Name:firre intergenic repeating RNA element
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC01200
Chromosome:X
Strand:-
Coordinate:
Start Site(bp):131691525End Site(bp):131830643
External Links:
Ensembl ID:ENSG00000213468
Ensembl Transcript ID:N/A
Entrez Gene:286467.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:8   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 0.985791)
Lymphoma, Large B-Cell, Diffuse  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Lymphoma, Large B-Cell, Diffuse  (Score: 0.985791)
Gallbladder Neoplasms  (Score: 0.731059)
Gallbladder Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0050745D016403
Disease Name:diffuse large B-cell lymphomaLymphoma, Large B-Cell, Diffuse
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A B-cell lymphoma that is a cancer of B cells presenting as an aggressive tumour which can arise in virtually any part of the body.Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.
Alias:Lymphoma, Large B-Cell, Diffuse//Lymphoma, Histiocytic//Histiocytic Lymphomas//Lymphoma, Large Lymphoid, Diffuse//Lymphoma, Histiocytic, Diffuse//Lymphoma, Large Cell, Diffuse//Lymphoma, Diffuse Large-Cell//Lymphoma, Diffuse Large Cell//Diffuse Large-Cell Lymphoma//Diffuse Large Cell Lymphoma//Diffuse Large-Cell Lymphomas//Diffuse, Large B-Cell, Lymphoma//Histiocytic Lymphoma//Histiocytic Lymphoma, Diffuse//Diffuse Histiocytic Lymphoma//Diffuse Histiocytic Lymphomas//Lymphoma, Diffuse Histiocytic//Large Lymphoid Lymphoma, Diffuse//Large-Cell Lymphoma, Diffuse//Large Cell Lymphoma, Diffuse//Diffuse Large B-Cell Lymphoma//Diffuse Large B Cell Lymphoma//Lymphoma, Large-Cell, Diffuse

 

Disease Association Statistics

Total Associated ncRNA Number:58   
More Information
Causal ncRNA Number:54
Network:
Top Causal ncRNAs:
FIRRE  (Score: 0.985791)
NEAT1  (Score: 0.985791)
SNHG14  (Score: 0.985791)
MALAT1  (Score: 0.985791)
FIRRE  (Score: 0.985791)
NEAT1  (Score: 0.985791)
SNHG14  (Score: 0.985791)
MALAT1  (Score: 0.985791)
circPCBP2  (Score: 0.731059)
circAPC  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:30739786
Disease Name:Lymphoma, Large B-Cell, Diffuse
Sample:DLBCL tissues and cells
Dysfunction Pattern:Regulation[Wnt/β-catenin signaling pathway]
Validated Method:qRT-PCR
Description:qRT-PCR proved that lncRNA functional intergenic repeating RNA element (FIRRE) was up-regulated in DLBCL tissues and cells. Taken together, FIRRE activated Wnt/β-catenin signaling pathway to facilitate DLBCL cell growth via modulation of the nuclear translocation of β-catenin.
Causality:Yes
Causal Description:Subsequently, cell functional assays further revealed that FIRRE functioned as an oncogene by promoting cell proliferation and reducing cell apoptosis in DLBCL.
Clinical-realted Application:Based on Kaplan-Meier analysis, high FIRRE level was associated with the poor overall survival.

[2] PubMed ID:35416325
Disease Name:Lymphoma, Large B-Cell, Diffuse
Sample:DLBCL cells
Dysfunction Pattern:Interaction(PTBP1/Smurf2 )
Validated Method:RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//MTT//Luciferase Report Assay//Colony Formation Assay
Description:FIRRE was specifically up-regulated in and essentially maintained multiple malignant behaviors of BCR-dependent DLBCL cells. Through the interaction with PTBP1, FIRRE promoted the mRNA decay of Smurf2, a ubiquitin ligase for the degradation BCR protein. Targeting FIRRE was sufficient to regulat Smurf2 and BCR expressions and inhibit DLBCL malignancy both in vivo and in vitro. FIRRE-PTBP1 interaction, by simulating Smurf2 mRNA decay and stabilizing BCR, promotes the development of DLBCL.
Causality:Yes
Causal Description:Targeting FIRRE was sufficient to regulat Smurf2 and BCR expressions and inhibit DLBCL malignancy both in vivo and in vitro.
Clinical-realted Application: