Entry Detail

General Information

Database ID: LDA0000628
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FGF14-AS2
Full Name:FGF14 antisense RNA 2
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:13
Strand:+
Coordinate:
Start Site(bp):102394578End Site(bp):102395705
External Links:
Ensembl ID:ENSG00000272143
Ensembl Transcript ID:N/A
Entrez Gene:283481.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.731059)
prostate carcinoma  (Score: 0.731059)
Glioma  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
prostate carcinoma  (Score: 0.731059)
Glioma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10286
Disease Name:prostate carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A prostate cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
Alias:cancer of prostate//carcinoma of prostate

 

Disease Association Statistics

Total Associated ncRNA Number:26   
More Information
Causal ncRNA Number:26
Network:
Top Causal ncRNAs:
PCBP2-OT1  (Score: 0.731059)
FGF14-AS2  (Score: 0.731059)
Erbb4-IR  (Score: 0.731059)
GAS5  (Score: 0.731059)
GASAL1  (Score: 0.731059)
BRE-AS1  (Score: 0.731059)
SNHG16  (Score: 0.731059)
hsa_circ_0102485  (Score: 0.731059)
MIR4435-2HG  (Score: 0.731059)
ZNF667-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//qRT-PCR//FISH//RIP//MTT//Luciferase Report Assay//IHC//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34655124
Disease Name:prostate carcinoma
Sample:prostate carcinoma tissue and cells
Dysfunction Pattern:Interaction(miR-96-5p/AJAP1 axis)
Validated Method:In Vivo Experiment//Western Blot//qRT-PCR//FISH//RIP//MTT//Luciferase Report Assay//IHC//Bioinformatics Analysis//Transwell Assay
Description:FGF14-AS2 was a downregulated lncRNA in prostate carcinoma tissue and cells. FGF14-AS2 could restrain miR-96-5p expression while miR-96-5p hampered AJAP1.Moreover, miR-96-5p mimic presented a cancer promoter role in prostate carcinoma cells. AJAP1 expression level could affect levels of proteins related to epithelial-mesenchymal transition.
Causality:Yes
Causal Description: FGF14-AS2 could effectively decrease the biological behaviors of prostate carcinoma cells, while knock-down of FGF14-AS2 triggered opposite results. In vivo experiment suggested that overexpressing FGF14-AS2 could reverse the promotion of silenced AJAP1 on prostate carcinoma cell metastasis, thus to inhibit tumor growth.
Clinical-realted Application: