Entry Detail

General Information

Database ID: LDA0000659
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:GACAT1
Full Name:gastric cancer associated transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00876
Chromosome:2
Strand:+
Coordinate:
Start Site(bp):107754112End Site(bp):107822129
External Links:
Ensembl ID:ENSG00000232991
Ensembl Transcript ID:N/A
Entrez Gene:104326057.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:8   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
tongue squamous cell carcinoma  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
tongue squamous cell carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0050865
Disease Name:tongue squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A head and neck squamous cell carcinoma that is located_in the tongue.
Alias:

 

Disease Association Statistics

Total Associated ncRNA Number:140   
More Information
Causal ncRNA Number:70
Network:
Top Causal ncRNAs:
hsa_circ_0001742  (Score: 1)
hsa_circ_0001742  (Score: 1)
MALAT1  (Score: 1)
MALAT1  (Score: 1)
CASC15  (Score: 0.985791)
hsa_circ_0002162  (Score: 0.985791)
CASC15  (Score: 0.985791)
hsa_circ_0000231  (Score: 0.985791)
hsa_circ_0002162  (Score: 0.985791)
hsa_circ_0000231  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Migration Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34378327
Disease Name:tongue squamous cell carcinoma
Sample:TSCC samples and cell lines
Dysfunction Pattern:Interaction(miR-149)
Validated Method:qRT-PCR//Migration Assay
Description: In this reference, we observed that GACAT1 was overexpressed in TSCC samples and cell lines. 25 TSCC specimens, GACAT1 expression was overexpressed in 18 patients (18/25, 72%) compared to non-tumour specimens. We observed that miR-149 expression was down-regulated in TSCC cell lines. Moreover, we observed that GACAT1 expression was negatively correlated with miR-149 expression. GACAT1 overexpression induced TSCC cell growth and migration via regulating miR-149 expression.
Causality:Yes
Causal Description:Ectopic expression of GACAT1 induced cell growth and migration and promoted epithelial to mesenchymal transition in TSCC. In addition, ectopic expression of GACAT1 decreased miR-149 expression in SCC1 cell.
Clinical-realted Application: