Entry Detail


General Information

Database ID: LDA0000683
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FOXD3-AS1
Full Name:FOXD3 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:FAST|pasFOXD3
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):63320884End Site(bp):63324441
External Links:
Ensembl ID:ENSG00000230798
Ensembl Transcript ID:N/A
Entrez Gene:100996301.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:24   
More Information
Causal Disease Number:24
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Nasopharyngeal carcinoma  (Score: 0.985791)
Lung Neoplasms  (Score: 0.985791)
Lung Neoplasms  (Score: 0.985791)
Nasopharyngeal carcinoma  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.731059)
skin melanoma  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8923
Disease Name:skin melanoma
Category:Disease Ontology
Type:Neoplasms
Define:A skin cancer that has_material_basis_in melanocytes.
Alias:cutaneous melanoma//malignant ear melanoma//malignant lip melanoma//malignant lower limb melanoma//malignant melanoma of ear and/or external auricular canal//malignant melanoma of skin of lower limb//malignant melanoma of skin of trunk except scrotum//malignant melanoma of skin of upper limb//malignant neck melanoma//malignant scalp melanoma//malignant trunk melanoma//malignant upper limb melanoma

 

Disease Association Statistics

Total Associated ncRNA Number:10   
More Information
Causal ncRNA Number:10
Network:
Top Causal ncRNAs:
HOXA11-AS  (Score: 0.731059)
HCP5  (Score: 0.731059)
HSD11B1-AS1  (Score: 0.731059)
FOXD2-AS1  (Score: 0.731059)
FOXD3-AS1  (Score: 0.731059)
HOXA11-AS  (Score: 0.731059)
HCP5  (Score: 0.731059)
HSD11B1-AS1  (Score: 0.731059)
FOXD2-AS1  (Score: 0.731059)
FOXD3-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//CCK8//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31541886
Disease Name:skin melanoma
Sample:cutaneous melanoma cells and tissues
Dysfunction Pattern:Interaction[miR-325/MAP3K2]
Validated Method:RNA Pull-Down//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay
Description: LncRNA FOXD3-AS1 highly expressed in cutaneous melanoma cells and tissues.LncRNA FOXD3-AS1 could promote proliferation, invasion and migration of cutaneous malignant melanoma via regulating miR-325/MAP3K2 axis.
Causality:Yes
Causal Description:When LncRNA FOXD3-AS1 was knockdown, proliferation, invasion and migration of cutaneous malignant melanoma, and tumor weight was inhibited, and cell cycle was arrested. Tumor volume and weight were measured to confirm the effect of sh-FOXD3-AS1 in vivo.
Clinical-realted Application: