LncRNADisease3

Entry Detail

General Information

Database ID:	LDA0000688
Species:	Homo sapiens
Confidence Score:	0.731059
Contents:	>> ncRNA Information >> ncRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference
Causality:	Yes
Clinical Significance:	Yes

ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:

FOXO1

Full Name:

forkhead box O1

Category:

LncRNA

Species:

Homo sapiens

Synonyms:

FKH1|FKHR|FOXO1A

Chromosome:

Strand:

Coordinate:

Start Site(bp):

40555667

End Site(bp):

40666641

External Links:

Ensembl ID:	ENSG00000150907
Ensembl Transcript ID:	N/A
Entrez Gene:	2308.0
NONCODE ID:	N/A
RefSeq Accession:	N/A

ncRNA Association Statistics

Total Associated Disease Number:

2 More Information

Causal Disease Number:

Network:

Top Causal Diseases:

Lung Neoplasms (Score: 0.731059)

More Information

Disease Information

	Disease Ontology	MeSH
Disease ID:	DOID:1324	D008175
Disease Name:	lung cancer	Lung Neoplasms
Category:	Disease Ontology	MeSH
Type:		Neoplasms
Define:	A respiratory system cancer that is located_in the lung.	Tumors or cancer of the LUNG.
Alias:		Lung Neoplasms//Pulmonary Neoplasms//Neoplasms, Lung//Lung Neoplasm//Neoplasm, Lung//Neoplasms, Pulmonary//Neoplasm, Pulmonary//Pulmonary Neoplasm//Lung Cancer//Cancer, Lung//Cancers, Lung//Lung Cancers//Pulmonary Cancer//Cancer, Pulmonary//Cancers, Pulmonary//Pulmonary Cancers//Cancer of the Lung//Cancer of Lung

Disease Association Statistics

Total Associated ncRNA Number:

344 More Information

Causal ncRNA Number:

282

Network:

Top Causal ncRNAs:

OIP5-AS1 (Score: 0.999893)

MNX1-AS1 (Score: 0.999893)

NEAT1 (Score: 0.999893)

MNX1-AS1 (Score: 0.999893)

NEAT1 (Score: 0.999893)

circHIPK3 (Score: 0.985791)

GAS5 (Score: 0.985791)

PCAT1 (Score: 0.985791)

NNT-AS1 (Score: 0.985791)

More Information

Evidence Support

Strong Evidence:	Western Blot//Migration Assay//qRT-PCR//MTT//cell invasion assay
Weak Evidence:

Reference

[1] PubMed ID:	31217928
Disease Name:	Lung Neoplasms
Sample:	lung cancer tissues and corresponding adjacent tissues,cell lines(A549, H460, HCC827 and H129IMR-90)
Dysfunction Pattern:	Regulation[PI3K/AKT signaling pathway]
Validated Method:	Western Blot//Migration Assay//qRT-PCR//MTT//cell invasion assay
Description:	LncFOXO1 was down-regulated in lung cancer tumor tissues and cells. LncFOXO1 inhibited lung cancer cell proliferation, metastasis, and induced apoptosis through down-regulating PI3K/AKT pathway.
Causality:	Yes
Causal Description:	Knockdown of lncFOXO1 significantly promoted A549 cells viability, colony formation and invasion.
Clinical-realted Application:

LncRNADisease v3.0

Entry Detail