Entry Detail

General Information

Database ID: LDA0000712
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ERLR
Full Name:long intergenic non-protein coding RNA 1705
Category:LncRNA
Species:Homo sapiens
Synonyms:ERLR
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):222041704End Site(bp):222059393
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:107985307.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Vitreoretinopathy, Proliferative  (Score: 0.731059)
Vitreoretinopathy, Proliferative  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9719D018630
Disease Name:neovascular inflammatory vitreoretinopathyVitreoretinopathy, Proliferative
Category:Disease OntologyMeSH
Type:Eye Diseases
Define:A retinal and vitreous disease characterized by ocular inflammation, vascular dropout, large spots of hyperpigmentation, neovascularization of the peripheral and posterior retina, vitreous hemorrhage, and retinal detachment that has_material_basis_in heterozygous mutation in CAPN5 on chromosome 11q13.5.Vitreoretinal membrane shrinkage or contraction secondary to the proliferation of primarily retinal pigment epithelial cells and glial cells, particularly fibrous astrocytes, followed by membrane formation. The formation of fibrillar collagen and cellular proliferation appear to be the basis for the contractile properties of the epiretinal and vitreous membranes.
Alias:ADNIV//Retinitis proliferans//autosomal dominant neovascular inflammatory vitreoretinopathy//proliferative vitreoretinopathyVitreoretinopathy, Proliferative//Proliferative Vitreoretinopathies//Vitreoretinopathies, Proliferative//Vitreoretinopathy Neovascular Inflammatory//Inflammatories, Vitreoretinopathy Neovascular//Inflammatory, Vitreoretinopathy Neovascular//Neovascular Inflammatories, Vitreoretinopathy//Neovascular Inflammatory, Vitreoretinopathy//Vitreoretinopathy Neovascular Inflammatories//Proliferative Vitreoretinopathy

 

Disease Association Statistics

Total Associated ncRNA Number:4   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
ERLR  (Score: 0.731059)
hsa_circ_0043144  (Score: 0.731059)
ERLR  (Score: 0.731059)
hsa_circ_0043144  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Migration Assay//FISH//qRT-PCR//IF//Transwell Assay//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:33664479
Disease Name:Vitreoretinopathy, Proliferative
Sample:RPE cells
Dysfunction Pattern:Interaction(TCF4/MYH9 )
Validated Method:RNA Pull-Down//ChIP//Western Blot//Migration Assay//FISH//qRT-PCR//Microarray//Transwell Assay//IF
Description:In this study, we found that ERLR is upregulated in RPE cells stimulated with transforming growth factor (TGF)-β1 as detected by lncRNA microarray and RT-PCR. Mechanistically, chromatin immunoprecipitation (ChIP) assays indicated that the transcription factor TCF4 directly binds to the promoter region of ERLR and promotes its transcription. ERLR mediates EMT by directly binding to MYH9 protein and increasing its stability. TCF4 and MYH9 also mediate TGF-β1-induced EMT in RPE cells.
Causality:Yes
Causal Description: In vitro, silencing ERLR in RPE cells attenuated TGF-β1-induced EMT, whereas overexpressing ERLR directly triggered EMT in RPE cells. In vivo, inhibiting ERLR in RPE cells reduced the ability of cells to induce experimental PVR.
Clinical-realted Application: