Entry Detail

General Information

Database ID: LDA0000719
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FALEC
Full Name:eukaryotic translation initiation factor 4A3
Category:LncRNA
Species:Homo sapiens
Synonyms:DDX48|Fal1|MUK34|NMP265|NUK34|RCPS|eIF-4A-III|eIF4A-III|eIF4AIII
Chromosome:17
Strand:-
Coordinate:
Start Site(bp):80134369End Site(bp):80147128
External Links:
Ensembl ID:ENSG00000228126
Ensembl Transcript ID:N/A
Entrez Gene:9775.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
Thyroid Cancer, Papillary  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
Thyroid Cancer, Papillary  (Score: 0.985791)
Endometrial Neoplasms  (Score: 0.731059)
tongue squamous cell carcinoma  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0050865
Disease Name:tongue squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A head and neck squamous cell carcinoma that is located_in the tongue.
Alias:

 

Disease Association Statistics

Total Associated ncRNA Number:140   
More Information
Causal ncRNA Number:70
Network:
Top Causal ncRNAs:
hsa_circ_0001742  (Score: 1)
hsa_circ_0001742  (Score: 1)
MALAT1  (Score: 1)
MALAT1  (Score: 1)
CASC15  (Score: 0.985791)
hsa_circ_0002162  (Score: 0.985791)
CASC15  (Score: 0.985791)
hsa_circ_0000231  (Score: 0.985791)
hsa_circ_0002162  (Score: 0.985791)
hsa_circ_0000231  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Transwell Assay//Wound Healing Assay//CCK8//qRT-PCR//RIP//Colony Formation Assay//EdU Staining//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:31335317
Disease Name:tongue squamous cell carcinoma
Sample:
Dysfunction Pattern:Interaction[ECM1 ]
Validated Method:RNA Pull-Down//ChIP//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP//Microarray//Colony Formation Assay//EdU Staining//Transwell Assay
Description:The focally amplified long non-coding RNA in epithelial cancer (FALEC) was found downregulated in the tissues of tongue squamous cell carcinoma (TSCC) and was predicted to present a good prognosis by bioinformatics analysis. RNA pull-down and RNA immunoprecipitation demonstrated that FALEC could recruit enhancer of zeste homolog 2 (EZH2) at the promoter regions of extracellular matrix protein 1 (ECM1), epigenetically repressing ECM1 expression. The data revealed that FALEC acted as a tumor suppressor in TSCC and may aid in developing a novel potential therapeutic strategy against TSCC.
Causality:Yes
Causal Description: Experiments indicated that FALEC knockdown significantly increased the proliferation and migration of TSCC cells both in vitro and in vivo; however, FALEC overexpression repressed these malignant behaviors.
Clinical-realted Application: