Entry Detail

General Information

Database ID: LDA0000724
Species: Homo sapiens
Confidence Score: 0.959542
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FAM225A
Full Name:family with sequence similarity 225 member A
Category:LncRNA
Species:Homo sapiens
Synonyms:C9orf109|LINC00256A|NCRNA00256A
Chromosome:9
Strand:+
Coordinate:
Start Site(bp):113112896End Site(bp):113119846
External Links:
Ensembl ID:ENSG00000231528
Ensembl Transcript ID:N/A
Entrez Gene:286333.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:6   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Nasopharyngeal carcinoma  (Score: 0.959542)
Nasopharyngeal carcinoma  (Score: 0.959542)
Stomach Neoplasms  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9261C538339
Disease Name:nasopharynx carcinomaNasopharyngeal carcinoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A pharynx cancer that is located in the nasopharynx, the uppermost region of the pharynx or throat, where the nasal passages and auditory tubes join the remainder of the upper respiratory tract.A carcinoma that originates in the nasopharyngeal EPITHELIUM and includes 4 subtypes: keratinizing squamous cell, nonkeratinizing, basaloid squamous cell, and PAPILLARY ADENOCARCINOMA. It is most prevalent in Southeast Asian populations and is associated with EPSTEIN-BARR VIRUS INFECTIONS. Somatic mutations have been identified in NPCR, BAP1, UBAP1, ERBB2, ERBB3, MLL2, PIK3CA, KRAS, NRAS, and ARID1A genes. OMIM: 607107
Alias:Nasopharyngeal carcinoma//malignant Nasopharyngeal tumor//malignant neoplasm of nasopharynx//nasopharynx cancer

 

Disease Association Statistics

Total Associated ncRNA Number:260   
More Information
Causal ncRNA Number:244
Network:
Top Causal ncRNAs:
ZFAS1  (Score: 1)
ZFAS1  (Score: 1)
DANCR  (Score: 0.999893)
XIST  (Score: 0.999893)
XIST  (Score: 0.999893)
DANCR  (Score: 0.999893)
circZNF609  (Score: 0.985791)
hsa_circ_0008450  (Score: 0.985791)
PVT1  (Score: 0.985791)
circZNF609  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Transfection//Migration Assay//CCK8//qRT-PCR//RIP//Invasion Assay
Weak Evidence:Other

 

Reference

[1] PubMed ID:31331909
Disease Name:Nasopharyngeal carcinoma
Sample:NPC tissues
Dysfunction Pattern:Interaction[Sponge miR-590-3p/miR-1275 and Upregulate ITGB3]
Validated Method:Other
Description:Here, based on a microarray analysis, we identified 384 dysregulated lncRNAs, of which, FAM225A was one of the most upregulated lncRNAs in NPC. Mechanistically, FAM225A functioned as a competing endogenous RNA (ceRNA) for sponging miR-590-3p and miR-1275, leading to the upregulation of their target integrin β3 (ITGB3), and the activation of FAK/PI3K/Akt signaling to promote NPC cell proliferation and invasion. In summary, our study reveals a potential ceRNA regulatory pathway in which FAM225A modulates ITGB3 expression by binding to miR-590-3p and miR-1275, ultimately promoting tumorigenesis and metastasis in NPC.
Causality:Yes
Causal Description:FAM225A functioned as an oncogenic lncRNA that promoted NPC cell proliferation, migration, invasion, tumor growth, and metastasis.
Clinical-realted Application:

[2] PubMed ID:35809496
Disease Name:Nasopharyngeal carcinoma
Sample:NPC tissues and cell lines
Dysfunction Pattern:Interaction(FUS/CENP-N )
Validated Method:RNA Pull-Down//Western Blot//Transfection//Migration Assay//CCK8//qRT-PCR//RIP//Invasion Assay
Description:FAM225A and CENP-N expression levels were evaluated in NPC tissues and cell lines. FAM225A stabilized CENP-N mRNA by recruiting FUS. FAM225A activated cGAS-STING by regulating the expression of CENP-N to promote NPC cell proliferation, migration and EMT.
Causality:Yes
Causal Description:FAM225A knockdown inhibited NPC cell proliferation, migration and EMT.
Clinical-realted Application: