Entry Detail

General Information

Database ID: LDA0000731
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FAM13A-AS1
Full Name:FAM13A antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:FAM13A1OS|FAM13AOS|NCRNA00039
Chromosome:4
Strand:+
Coordinate:
Start Site(bp):88709789End Site(bp):88730103
External Links:
Ensembl ID:ENSG00000248019
Ensembl Transcript ID:N/A
Entrez Gene:285512.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:6   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Uterine Cervical Neoplasms  (Score: 0.731059)
Carcinoma, Renal Cell  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Carcinoma, Renal Cell  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4362D002583
Disease Name:cervical cancerUterine Cervical Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A female reproductive organ cancer that is located_in the cervix.Tumors or cancer of the UTERINE CERVIX.
Alias:cervical neoplasm//cervix cancer//cervix uteri cancer//neoplasm of uterine cervix//tumor of the Cervix Uteri//uterine cervical neoplasmUterine Cervical Neoplasms//Cervical Neoplasm, Uterine//Neoplasm, Uterine Cervical//Uterine Cervical Neoplasm//Neoplasms, Cervical//Cervical Neoplasms//Cervical Neoplasm//Neoplasms, Cervix//Cervix Neoplasm//Neoplasm, Cervix//Cervix Neoplasms//Cancer of the Uterine Cervix//Cancer of the Cervix//Cervical Cancer//Cancer, Cervical//Cervical Cancers//Uterine Cervical Cancer//Cancer, Uterine Cervical//Cervical Cancer, Uterine//Uterine Cervical Cancers//Cancer of Cervix//Cervix Cancer//Cancer, Cervix

 

Disease Association Statistics

Total Associated ncRNA Number:15334   
More Information
Causal ncRNA Number:532
Network:
Top Causal ncRNAs:
UCA1  (Score: 1)
CRNDE  (Score: 1)
WT1-AS  (Score: 1)
PVT1  (Score: 1)
LINC00511  (Score: 1)
DARS1-AS1  (Score: 1)
UCA1  (Score: 1)
NEAT1  (Score: 1)
OIP5-AS1  (Score: 1)
CRNDE  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//ISH//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//IHC//Invasion Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35783157
Disease Name:Uterine Cervical Neoplasms
Sample:cervical cancer tissues and cell lines
Dysfunction Pattern:Interaction(miRNA-205-3p/DDI2 Axis)
Validated Method:In Vivo Experiment//Western Blot//ISH//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//IHC//Invasion Assay//Transwell Assay
Description:. Low FAM13A-AS1 expression and high miRNA-205-3p expression were observed in cervical cancer tissues and cell lines (SiHa and HeLa). In addition, FAM13A-AS1 negatively regulated the expression of miRNA-205-3p, while miRNA-205-3p reduced DDI2 expression, and miRNA-205-3p mimic reversed the effects of FAM13A-AS1 overexpression in vitro.
Causality:Yes
Causal Description: Upregulating the expression of FAM13A-AS1 inhibited proliferation, migration, and invasion of SiHa and HeLa cells, while the apoptosis of SiHa and HeLa cells was increased. More importantly, LV-FAM13A-AS1 could improve tumor development in vivo.
Clinical-realted Application: