Entry Detail

General Information

Database ID: LDA0000753
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ENO1
Full Name:enolase 1
Category:LncRNA
Species:Homo sapiens
Synonyms:ENO1-IT1|ENO1L1|HEL-S-17|MPB1|NNE|PPH
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):8861000End Site(bp):8878686
External Links:
Ensembl ID:ENSG00000074800
Ensembl Transcript ID:N/A
Entrez Gene:2023.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Adenocarcinoma of Lung  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3910D000077192
Disease Name:lung adenocarcinomaAdenocarcinoma of Lung
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin.A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.
Alias:bronchogenic lung adenocarcinoma//nonsmall cell adenocarcinomaAdenocarcinoma of Lung//Lung Adenocarcinomas//Lung Adenocarcinoma//Adenocarcinoma, Lung//Adenocarcinomas, Lung

 

Disease Association Statistics

Total Associated ncRNA Number:656   
More Information
Causal ncRNA Number:386
Network:
Top Causal ncRNAs:
LINC00665  (Score: 1)
LINC00511  (Score: 1)
FAM83A-AS1  (Score: 1)
LINC00665  (Score: 1)
LINC00511  (Score: 1)
FAM83A-AS1  (Score: 1)
CCAT1  (Score: 0.999893)
H19  (Score: 0.999893)
SNHG17  (Score: 0.999893)
LINC00467  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:TUNEL//Western Blot//ISH//Wound Healing Assay//Tunel//qRT-PCR//RIP//FISH//PCR//IP//IHC//IF
Weak Evidence:

 

Reference

[1] PubMed ID:31767835
Disease Name:Adenocarcinoma of Lung
Sample:cell lines
Dysfunction Pattern:Regulation[miR-22-3p/ENO1 axis]
Validated Method:TUNEL//Western Blot//ISH//Wound Healing Assay//Tunel//qRT-PCR//RIP//FISH//PCR//IP//IHC//IF
Description:Circ-ENO1 and its host gene ENO1 were identified to be upregulated in LUAD cells.In summary, current study elucidated that circ-ENO1 promoted glycolysis and tumor progression in LUAD by miR-22-3p/ENO1 axis, indicating circ-ENO1 as a promising treatment target for LUAD patients.
Causality:Yes
Causal Description:Functionally, silencing circ-ENO1 retarded glycolysis, inhibited proliferation, migration and EMT, induced apoptosis.
Clinical-realted Application: