Entry Detail

General Information

Database ID: LDA0000755
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:EMX2OS
Full Name:EMX2 opposite strand/antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:EMX2-AS1|NCRNA00045
Chromosome:10
Strand:-
Coordinate:
Start Site(bp):117484293End Site(bp):117545068
External Links:
Ensembl ID:ENSG00000229847
Ensembl Transcript ID:N/A
Entrez Gene:196047.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Ovarian Neoplasms  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Wilms Tumor  (Score: 0.548294)
Wilms Tumor  (Score: 0.548294)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10283D011471
Disease Name:prostate cancerProstatic Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A male reproductive organ cancer that is located_in the prostate.Tumors or cancer of the PROSTATE.
Alias:NGP - new growth of prostate//hereditary prostate cancer//malignant tumor of the prostate//prostate cancer, familial//prostate neoplasm//prostatic cancer//prostatic neoplasm//tumor of the prostateProstatic Neoplasms//Prostate Neoplasms//Neoplasms, Prostate//Neoplasm, Prostate//Prostate Neoplasm//Neoplasms, Prostatic//Neoplasm, Prostatic//Prostatic Neoplasm//Prostate Cancer//Cancer, Prostate//Cancers, Prostate//Prostate Cancers//Cancer of the Prostate//Prostatic Cancer//Cancer, Prostatic//Cancers, Prostatic//Prostatic Cancers//Cancer of Prostate

 

Disease Association Statistics

Total Associated ncRNA Number:566   
More Information
Causal ncRNA Number:414
Network:
Top Causal ncRNAs:
TUG1  (Score: 1)
SNHG1  (Score: 1)
MALAT1  (Score: 1)
NORAD  (Score: 1)
NEAT1  (Score: 1)
circHIPK3  (Score: 1)
SNHG3  (Score: 1)
MALAT1  (Score: 1)
SNHG1  (Score: 1)
NORAD  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//RNA Pull-Down//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:32801740
Disease Name:Prostatic Neoplasms
Sample:PCa tissues
Dysfunction Pattern:regulation[cGMP-PKG pathway]
Validated Method:qRT-PCR//RNA Pull-Down//ChIP
Description: TCF12 and EMX2OS were both downregulated in PCa tissues and cells,EMX2OS, transcriptionally regulated by TCF12, played a synergy role with FUS protein in regulating the proliferation, migration and invasion of PCa cells by activating the cGMP-PKG pathway.
Causality:Yes
Causal Description:TCF12 and EMX2OS were both downregulated in PCa tissues and cells, and they negatively regulated cell proliferation, migration and invasion, and activated cGMP-PKG pathway in DU145 and PC3 cells.
Clinical-realted Application: