Entry Detail

General Information

Database ID: LDA0000756
Species: Homo sapiens
Confidence Score: 0.548294
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:EMX2OS
Full Name:EMX2 opposite strand/antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:EMX2-AS1|NCRNA00045
Chromosome:10
Strand:-
Coordinate:
Start Site(bp):117484293End Site(bp):117545068
External Links:
Ensembl ID:ENSG00000229847
Ensembl Transcript ID:N/A
Entrez Gene:196047.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Ovarian Neoplasms  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Wilms Tumor  (Score: 0.548294)
Wilms Tumor  (Score: 0.548294)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2154D009396
Disease Name:nephroblastomaWilms Tumor
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A kidney cancer that affects the kidneys and typically located_in children.A malignant kidney tumor, caused by the uncontrolled multiplication of renal stem (blastemal), stromal (STROMAL CELLS), and epithelial (EPITHELIAL CELLS) elements. However, not all three are present in every case. Several genes or chromosomal areas have been associated with Wilms tumor which is usually found in childhood as a firm lump in a child's side or ABDOMEN.
Alias:adult nephroblastomaWilms Tumor//Tumor, Wilms//Wilms' Tumor//Tumor, Wilms'//Wilm Tumor//Wilm's Tumor//Wilms Tumor 1//Nephroblastoma//Nephroblastomas//Bilateral Wilms Tumor//Tumor, Bilateral Wilms//Wilms Tumor, Bilateral

 

Disease Association Statistics

Total Associated ncRNA Number:36   
More Information
Causal ncRNA Number:34
Network:
Top Causal ncRNAs:
XIST  (Score: 0.985791)
XIST  (Score: 0.985791)
OSTM1-AS1  (Score: 0.731059)
SOX21-AS1  (Score: 0.731059)
circNCKAP1  (Score: 0.731059)
CRNDE  (Score: 0.731059)
H19  (Score: 0.731059)
HAGLROS  (Score: 0.731059)
hsa_circ_0093741  (Score: 0.731059)
DLEU2  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:
Weak Evidence:Other

 

Reference

[1] PubMed ID:35181613
Disease Name:Wilms Tumor
Sample:Wilms' tumor patient samples
Dysfunction Pattern:Interaction(miR-654-3p)
Validated Method:Other
Description:EMX2OS expression was lower, while miR-654-3p level was higher in Wilms' tumor patient samples, and there was a negative correlation between EMX2OS and miR-654-3p. EMX2OS acted as a sponge of miR-654-3p. Overexpression of miR-654-3p abolished EMX2OS-mediated anti-cancer effects on Wilms' tumor cells.
Causality:Yes
Causal Description:Overexpression of EMX2OS repressed growth, migration, invasion, and triggered apoptosis of Wilms' tumor cells.Finally, EMX2OS overexpression restrained Wilms' tumor growth in vivo.
Clinical-realted Application: