Entry Detail

General Information

Database ID: LDA0000767
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:EPIC1
Full Name:epigenetically induced MYC interacting lncRNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:Lnc-EPIC1
Chromosome:22
Strand:+
Coordinate:
Start Site(bp):47631674End Site(bp):47855600
External Links:
Ensembl ID:ENSG00000224271
Ensembl Transcript ID:N/A
Entrez Gene:284930.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:16   
More Information
Causal Disease Number:14
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Lung Neoplasms  (Score: 0.731059)
Colonic Neoplasms  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Pancreatic Neoplasms  (Score: 0.731059)
Gallbladder Neoplasms  (Score: 0.731059)
Cholangiocarcinoma  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Lung Neoplasms  (Score: 0.731059)
Colonic Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1324D008175
Disease Name:lung cancerLung Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A respiratory system cancer that is located_in the lung.Tumors or cancer of the LUNG.
Alias:Lung Neoplasms//Pulmonary Neoplasms//Neoplasms, Lung//Lung Neoplasm//Neoplasm, Lung//Neoplasms, Pulmonary//Neoplasm, Pulmonary//Pulmonary Neoplasm//Lung Cancer//Cancer, Lung//Cancers, Lung//Lung Cancers//Pulmonary Cancer//Cancer, Pulmonary//Cancers, Pulmonary//Pulmonary Cancers//Cancer of the Lung//Cancer of Lung

 

Disease Association Statistics

Total Associated ncRNA Number:344   
More Information
Causal ncRNA Number:282
Network:
Top Causal ncRNAs:
OIP5-AS1  (Score: 0.999893)
OIP5-AS1  (Score: 0.999893)
MNX1-AS1  (Score: 0.999893)
NEAT1  (Score: 0.999893)
MNX1-AS1  (Score: 0.999893)
NEAT1  (Score: 0.999893)
circHIPK3  (Score: 0.985791)
GAS5  (Score: 0.985791)
PCAT1  (Score: 0.985791)
NNT-AS1  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:30029875
Disease Name:Lung Neoplasms
Sample: lung cancer tissues,epithelial cells
Dysfunction Pattern:interaction[MYC]
Validated Method:qRT-PCR
Description:We show that Lnc-EPIC1 expression is significantly higher in established/primary human lung cancer cells than that in human lung epithelial cells. Lnc-EPIC1 is also elevated in human lung cancer tissues. Together, our results show that Lnc-EPIC1 promotes human lung cancer cell growth possibly by targeting MYC.
Causality:Yes
Causal Description:Silencing of Lnc-EPIC1 by targeted siRNA significantly inhibited human lung cancer cell growth, survival and proliferation, whiling inducing G1-S cell cycle arrest and cell apoptosis.
Clinical-realted Application: