Entry Detail

General Information

Database ID: LDA0000771
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:EPIC1
Full Name:epigenetically induced MYC interacting lncRNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:Lnc-EPIC1
Chromosome:22
Strand:+
Coordinate:
Start Site(bp):47631674End Site(bp):47855600
External Links:
Ensembl ID:ENSG00000224271
Ensembl Transcript ID:N/A
Entrez Gene:284930.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:16   
More Information
Causal Disease Number:14
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Lung Neoplasms  (Score: 0.731059)
Colonic Neoplasms  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Pancreatic Neoplasms  (Score: 0.731059)
Gallbladder Neoplasms  (Score: 0.731059)
Cholangiocarcinoma  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Lung Neoplasms  (Score: 0.731059)
Colonic Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3121D005706
Disease Name:gallbladder cancerGallbladder Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A biliary tract cancer that is located_in the gallbladder.Tumors or cancer of the gallbladder.
Alias:gallbladder Ca//gallbladder neoplasm//localized malignant gallbladder neoplasm//malignant neoplasm of gallbladder//malignant tumor of the gallbladder//malignant tumour of gallbladder//tumor of the gallbladderGallbladder Neoplasms//Gallbladder Neoplasm//Neoplasm, Gallbladder//Neoplasms, Gallbladder//Cancer of Gallbladder//Gallbladder Cancers//Gallbladder Cancer//Cancer, Gallbladder//Cancers, Gallbladder//Gall Bladder Cancer//Bladder Cancer, Gall//Bladder Cancers, Gall//Cancer, Gall Bladder//Cancers, Gall Bladder//Gall Bladder Cancers//Cancer of the Gallbladder

 

Disease Association Statistics

Total Associated ncRNA Number:52   
More Information
Causal ncRNA Number:38
Network:
Top Causal ncRNAs:
PVT1  (Score: 0.999893)
PVT1  (Score: 0.999893)
MEG3  (Score: 0.985791)
MEG3  (Score: 0.985791)
LINC01410  (Score: 0.731059)
FOXD2-AS1  (Score: 0.731059)
RP11-147L13.8  (Score: 0.731059)
HOXA-AS2  (Score: 0.731059)
EPIC1  (Score: 0.731059)
FIRRE  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:CCK8//qPCR//Cell Apoptosis Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34653690
Disease Name:Gallbladder Neoplasms
Sample:plasma and paracancerous tissues of GBC patients
Dysfunction Pattern:Interaction(LncRNA LET)
Validated Method:CCK8//qPCR//Cell Apoptosis Assay
Description:The present study found that EPIC1 was upregulated in tumor tissues than in paracancerous tissues of GBC patients, and plasma levels of EPIC1 were significantly correlated with levels of EPIC1 in tumor tissues. LncRNA LET was downregulated in tumor tissues than in paracancerous tissues and was inversely correlated with EPIC1 in both tumor tissues and paracancerous tissues.
Causality:Yes
Causal Description:Overexpression of EPIC1 led to downregulated LET, and LET overexpression also mediated the downregulation of EPIC1. EPIC1 led to accelerated GBC cell proliferation and inhibited apoptosis. Overexpression of LET played opposites roles.
Clinical-realted Application: