Entry Detail

General Information

Database ID: LDA0000775
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:EPB41L5
Full Name:erythrocyte membrane protein band 4.1 like 5
Category:LncRNA
Species:Homo sapiens
Synonyms:BE37|LULU|LULU1|YMO1|YRT
Chromosome:2
Strand:+
Coordinate:
Start Site(bp):120013077End Site(bp):120179119
External Links:
Ensembl ID:ENSG00000115109
Ensembl Transcript ID:N/A
Entrez Gene:57669.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Glioblastoma  (Score: 0.731059)
Glioblastoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3068D005909
Disease Name:glioblastomaGlioblastoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A malignant astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes.A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
Alias:GBM//adult glioblastoma multiforme//grade IV adult Astrocytic tumor//primary glioblastoma multiforme//spongioblastoma multiformeGlioblastoma//Glioblastomas//Astrocytoma, Grade IV//Astrocytomas, Grade IV//Grade IV Astrocytoma//Grade IV Astrocytomas//Glioblastoma Multiforme//Giant Cell Glioblastoma//Giant Cell Glioblastomas//Glioblastoma, Giant Cell//Glioblastomas, Giant Cell

 

Disease Association Statistics

Total Associated ncRNA Number:296   
More Information
Causal ncRNA Number:252
Network:
Top Causal ncRNAs:
DLEU1  (Score: 0.999893)
LINC-ROR  (Score: 0.999893)
MALAT1  (Score: 0.999893)
HOTAIRM1  (Score: 0.999893)
LINC-ROR  (Score: 0.999893)
MALAT1  (Score: 0.999893)
HOTAIRM1  (Score: 0.999893)
DLEU1  (Score: 0.999893)
hsa_circ_0029426  (Score: 0.985791)
DLGAP1-AS1  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//RNA Pull-Down//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31905344
Disease Name:Glioblastoma
Sample:glioblastoma tissues and cell lines
Dysfunction Pattern:interaction[EPB41L5,miR-19a]
Validated Method:qRT-PCR//Luciferase Report Assay//RNA Pull-Down
Description:Circ-EPB41L5 was downregulated in glioblastoma tissues and cell lines compared to the normal brain tissues and cell lines. The current study highlights a novel suppressive function of circ-EPB41L5 and reveals that circ-EPB41L5/miR-19a/EPB41L5/p-AKT regulatory axis plays a striking role in the progression of glioblastoma, which provides a novel insight into the mechanisms underlying glioblastoma.
Causality:Yes
Causal Description: Low circ-EPB41L5 expression was correlated to the poor prognosis of glioblastoma patients, while the overexpression inhibited proliferation, clone formation, migration, and invasion abilities of glioma cells, and the suppression had counter effects.
Clinical-realted Application: Low circ-EPB41L5 expression was correlated to the poor prognosis of glioblastoma patients, while the overexpression inhibited proliferation, clone formation, migration, and invasion abilities of glioma cells, and the suppression had counter effects.