Entry Detail

General Information

Database ID: LDA0000780
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:EPB41L4A-AS1
Full Name:EPB41L4A antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:C5orf26|NCRNA00219|TIGA1
Chromosome:5
Strand:+
Coordinate:
Start Site(bp):112160526End Site(bp):112162501
External Links:
Ensembl ID:ENSG00000224032
Ensembl Transcript ID:N/A
Entrez Gene:114915.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:6   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 0.731059)
Aging  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Aging  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D000375
Disease Name:Aging
Category:MeSH
Type:Physiological Phenomena
Define:The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Alias:Aging//Senescence//Biological Aging//Aging, Biological

 

Disease Association Statistics

Total Associated ncRNA Number:6   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
EPB41L4A-AS1  (Score: 0.731059)
circGSE1  (Score: 0.731059)
EPB41L4A-AS1  (Score: 0.731059)
circGSE1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Transfection//Western Blot//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:34758883
Disease Name:Aging
Sample:neurons and glial-derived cells.
Dysfunction Pattern:Regulation(damaging synthesis of NAD+ and ATP)
Validated Method:Western Blot//Transfection//qRT-PCR//Bioinformatics Analysis//ChIP
Description:EPB41L4A-AS1 was downregulated in aging and Alzheimer's disease. EPB41L4A-AS1 related genes were found to be enriched in the electron transport chain and NAD synthesis pathway. Furthermore, these genes were highly associated with neurodegenerative diseases and positively correlated with EPB41L4A-AS1. In addition, biological experiments proved that the downregulation of EPB41L4A-AS1 could reduce the expression of these genes via histone H3 lysine 27 acetylation, resulting in decreased NAD and ATP levels, while EPB41L4A-AS1 overexpression and nicotinamide riboside treatment could restore the NAD and ATP levels.
Causality:Yes
Causal Description:biological experiments proved that the downregulation of EPB41L4A-AS1 could reduce the expression of these genes via histone H3 lysine 27 acetylation, resulting in decreased NAD and ATP levels, while EPB41L4A-AS1 overexpression and nicotinamide riboside treatment could restore the NAD and ATP levels.
Clinical-realted Application: