LncRNADisease3

Entry Detail

General Information

Database ID:	LDA0000788
Species:	Homo sapiens
Confidence Score:	0.731059
Contents:	>> ncRNA Information >> ncRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference
Causality:	Yes
Clinical Significance:	Unknown

ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:

FER1L4

Full Name:

fer-1 like family member 4 (pseudogene)

Category:

LncRNA

Species:

Homo sapiens

Synonyms:

C20orf124

Chromosome:

Strand:

Coordinate:

Start Site(bp):

35558737

End Site(bp):

35607562

External Links:

Ensembl ID:	ENSG00000088340
Ensembl Transcript ID:	N/A
Entrez Gene:	80307.0
NONCODE ID:	N/A
RefSeq Accession:	N/A

ncRNA Association Statistics

Total Associated Disease Number:

32 More Information

Causal Disease Number:

Network:

Top Causal Diseases:

Osteosarcoma (Score: 0.999893)

Squamous Cell Carcinoma of Head and Neck (Score: 0.985791)

Lung Neoplasms (Score: 0.985791)

Carcinoma, Hepatocellular (Score: 0.985791)

Squamous Cell Carcinoma of Head and Neck (Score: 0.985791)

Lung Neoplasms (Score: 0.985791)

Carcinoma, Hepatocellular (Score: 0.985791)

Colorectal Neoplasms (Score: 0.959542)

More Information

Disease Information

	Disease Ontology	MeSH
Disease ID:		D005910
Disease Name:		Glioma
Category:		MeSH
Type:		Neoplasms
Define:		Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Alias:		Glioma//Gliomas//Glial Cell Tumors//Glial Cell Tumor//Tumor, Glial Cell//Tumors, Glial Cell//Mixed Glioma//Glioma, Mixed//Gliomas, Mixed//Mixed Gliomas//Malignant Glioma//Glioma, Malignant//Gliomas, Malignant//Malignant Gliomas

Disease Association Statistics

Total Associated ncRNA Number:

660 More Information

Causal ncRNA Number:

606

Network:

Top Causal ncRNAs:

H19 (Score: 1)

MEG3 (Score: 1)

UCA1 (Score: 1)

GAS5 (Score: 1)

FOXD2-AS1 (Score: 1)

NEAT1 (Score: 1)

MEG3 (Score: 1)

PVT1 (Score: 1)

More Information

Evidence Support

Strong Evidence:	CCK8//qRT-PCR//Luciferase Report Assay//Western Blot
Weak Evidence:

Reference

[1] PubMed ID:	30887657
Disease Name:	Glioma
Sample:	glioma tissues
Dysfunction Pattern:	Interaction[FER1L4/miR-372/E2F1]
Validated Method:	CCK8//qRT-PCR//Luciferase Report Assay//Western Blot
Description:	In this study, it was found that the expression of LncRNA FER1L4 is upregulated in high-grade gliomas than in low-grade cases and that a high expression of LncRNA FER1L4 predicts poor prognosis of gliomas.Besides, it is found in our study that LncRNA FER1L4 expression is positively correlated with E2F1 mRNA expression. After knockdown of FER1L4 expression, E2F1 expression is significantly down-regulated, whereas the expression of miR-372 is significantly up-regulated; the up-regulation of miR-372 leads to significant down-regulation of FER1L4 and E2F1 expression. In addition, it is also found that FER1L4 can be used as competitive endogenous RNA to interact or bind with miR-371 and thereby up-regulate E2F1, thus promoting the cycle and proliferation of glioma cells. It may be one of the molecular mechanisms in which FER1L4 plays its oncogene-like role in gliomas.
Causality:	Yes
Causal Description:	Meanwhile, in vitro study suggests that expression of FER1L4 with SiRNA knockdown obviously suppresses cell cycle and proliferation. It is further demonstrated by experiments that the FER1L4 knockdown suppresses growth of in vivo glioma.
Clinical-realted Application:

LncRNADisease v3.0

Entry Detail