Entry Detail

General Information

Database ID: LDA0000789
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FER1L4
Full Name:fer-1 like family member 4 (pseudogene)
Category:LncRNA
Species:Homo sapiens
Synonyms:C20orf124
Chromosome:20
Strand:-
Coordinate:
Start Site(bp):35558737End Site(bp):35607562
External Links:
Ensembl ID:ENSG00000088340
Ensembl Transcript ID:N/A
Entrez Gene:80307.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:32   
More Information
Causal Disease Number:22
Network:
Top Causal Diseases:
Osteosarcoma  (Score: 0.999893)
Osteosarcoma  (Score: 0.999893)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Lung Neoplasms  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Lung Neoplasms  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.959542)
Colorectal Neoplasms  (Score: 0.959542)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D000077273
Disease Name:Thyroid Cancer, Papillary
Category:MeSH
Type:Neoplasms
Define:An ADENOCARCINOMA that originates from follicular cells of the THYROID GLAND and accounts for the majority of THYROID CANCER cases. Cells exhibit enlarged, oval, or elongated morphologies with clear, round, nuclei. Fusions of RET, NTRK1, TPM3, and PCM1 genes are associated with this cancer.
Alias:Thyroid Cancer, Papillary//Cancer, Papillary Thyroid//Cancers, Papillary Thyroid//Papillary Thyroid Cancer//Papillary Thyroid Cancers//Thyroid Cancers, Papillary//Thyroid Carcinoma, Papillary//Carcinoma, Papillary Thyroid//Carcinomas, Papillary Thyroid//Papillary Thyroid Carcinomas//Thyroid Carcinomas, Papillary//Papillary Carcinoma Of Thyroid//Papillary Thyroid Carcinoma//Familial Nonmedullary Thyroid Cancer//Nonmedullary Thyroid Carcinoma//Carcinoma, Nonmedullary Thyroid//Carcinomas, Nonmedullary Thyroid//Nonmedullary Thyroid Carcinomas//Thyroid Carcinoma, Nonmedullary//Thyroid Carcinomas, Nonmedullary

 

Disease Association Statistics

Total Associated ncRNA Number:340   
More Information
Causal ncRNA Number:280
Network:
Top Causal ncRNAs:
UCA1  (Score: 0.999893)
UCA1  (Score: 0.999893)
HOTAIR  (Score: 0.999893)
LINC00460  (Score: 0.999893)
HOTAIR  (Score: 0.999893)
LINC00460  (Score: 0.999893)
BICDL3P  (Score: 0.999358)
BICDL3P  (Score: 0.999358)
hsa_circ_0000644  (Score: 0.985791)
circRAPGEF5  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Migration Assay//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Proliferation Assay//IHC//Invasion Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34289835
Disease Name:Thyroid Cancer, Papillary
Sample:PTC tissues
Dysfunction Pattern:Interaction( miR-612/ Cadherin 4 axis)
Validated Method:In Vivo Experiment//RNA Pull-Down//Western Blot//Bioinformatics Analysis//Transfection//Migration Assay//Flow Cytometry//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Proliferation Assay//IHC//Invasion Assay
Description:Upregulated expression of FER1L4 in PTC tissues was positively correlated with lymph node metastasis (P = 0.020), extrathyroidal extension (P = 0.013) and advanced TNM stages (P = 0.013). Mechanistically, FER1L4 could competitively bind with miR-612 to prevent the degradation of its target gene CDH4. This condition was further confirmed in the rescue assays.
Causality:Yes
Causal Description:In addition, knockdown of FER1L4 suppressed PTC cell proliferation, migration, and invasion, whereas ectopic expression of FER1L4 inversely promoted these processes.
Clinical-realted Application:Upregulated expression of FER1L4 in PTC tissues was positively correlated with lymph node metastasis (P = 0.020), extrathyroidal extension (P = 0.013) and advanced TNM stages (P = 0.013).