Entry Detail

General Information

Database ID: LDA0000805
Species: Homo sapiens
Confidence Score: 1
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FEZF1-AS1
Full Name:FEZF1 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):122303658End Site(bp):122310077
External Links:
Ensembl ID:ENSG00000230316
Ensembl Transcript ID:N/A
Entrez Gene:154860.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:30   
More Information
Causal Disease Number:30
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Retinoblastoma  (Score: 0.999893)
Retinoblastoma  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Ovarian Neoplasms  (Score: 0.985791)
Glioblastoma  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3908D002289
Disease Name:lung non-small cell carcinomaCarcinoma, Non-Small-Cell Lung
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Alias:NSCLC//Non-small cell lung cancer//non-small cell lung carcinomaCarcinoma, Non-Small-Cell Lung//Carcinoma, Non Small Cell Lung//Carcinomas, Non-Small-Cell Lung//Lung Carcinoma, Non-Small-Cell//Lung Carcinomas, Non-Small-Cell//Non-Small-Cell Lung Carcinomas//Non-Small-Cell Lung Carcinoma//Non Small Cell Lung Carcinoma//Carcinoma, Non-Small Cell Lung//Non-Small Cell Lung Carcinoma//Non-Small Cell Lung Cancer//Nonsmall Cell Lung Cancer

 

Disease Association Statistics

Total Associated ncRNA Number:1090   
More Information
Causal ncRNA Number:936
Network:
Top Causal ncRNAs:
AFAP1-AS1  (Score: 1)
FEZF1-AS1  (Score: 1)
BCYRN1  (Score: 1)
GAS5  (Score: 1)
MALAT1  (Score: 1)
MAGI2-AS3  (Score: 1)
AWPPH  (Score: 1)
DANCR  (Score: 1)
hsa_circ_0007385  (Score: 1)
hsa_circ_0074027  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//qPCR//qRT-PCR//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33174014
Disease Name:Carcinoma, Non-Small-Cell Lung
Sample:NSCLC tissues
Dysfunction Pattern:regulation[ITGA11/miR-516b-5p axis]
Validated Method:qRT-PCR//Luciferase Report Assay//RNA Pull-Down//Microarray
Description:In the present study, FEZF1?AS1 was selected using Arraystar Human lncRNA microarray and was identified to be upregulated in NSCLC tissues and negatively associated with the overall survival of patients with NSCLC. Overall, the present findings demonstrated that FEZF1‑AS1 was upregulated and acted as an oncogene in NSCLC by regulating the ITGA11/miR‑516b‑5p axis, suggesting that FEZF1‑AS1 may be a potential prognostic biomarker and therapeutic target for NSCLC.
Causality:Yes
Causal Description:Loss?of?function assays revealed that FEZF1?AS1 inhibition decreased cell proliferation and migration, and arrested cells at the G2/M cell cycle phase.
Clinical-realted Application:In the present study, FEZF1?AS1 was selected using Arraystar Human lncRNA microarray and was identified to be upregulated in NSCLC tissues and negatively associated with the overall survival of patients with NSCLC.

[2] PubMed ID:32349744
Disease Name:Carcinoma, Non-Small-Cell Lung
Sample:NSCLC patients
Dysfunction Pattern:interaction[NOTCH1,miR-34a]
Validated Method:qPCR//Western Blot//Transwell Assay
Description:FEZF1-AS1 was up-regulated in NSCLC patients. FEZF1-AS1 promoted NSCLC cell migration and invasion through the up-regulation of NOTCH1 by serving as a sponge of miR-34a.
Causality:Yes
Causal Description:Analysis of cell migration and invasion showed increased cell invasion and migration rates after FEZF1-AS1 and NOTCH-1 over-expression.
Clinical-realted Application:Increased expression levels of FEZF1-AS1 were observed with the increase in clinical stages.

[3] PubMed ID:32020063
Disease Name:Carcinoma, Non-Small-Cell Lung
Sample:NSCLC tissues
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR//Microarray
Description:The selected lncRNAs for technical and biological qPCR-based validation (Supplementary Table S5) were FEZF1-AS1, LINC01214, LINC00673, PCAT6, NUTM2A-AS1, RNF139-AS1, LINC01929, HMGA1P4 (upregulated) and PCAT19, FENDRR, SVIL-AS1, LANCL1-AS1, ADAMTS9-AS2 and LINC00968 (downregulated).
Causality:No
Causal Description:
Clinical-realted Application:

[4] PubMed ID:32590821
Disease Name:Carcinoma, Non-Small-Cell Lung
Sample:Plasma
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR
Description:Plasma FEZF1-AS1 of the NSCLC group was increased compared with that in the control group (P < .0001).
Causality:No
Causal Description:
Clinical-realted Application: