Entry Detail

General Information

Database ID: LDA0000806
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FEZF1-AS1
Full Name:FEZF1 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):122303658End Site(bp):122310077
External Links:
Ensembl ID:ENSG00000230316
Ensembl Transcript ID:N/A
Entrez Gene:154860.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:30   
More Information
Causal Disease Number:30
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Retinoblastoma  (Score: 0.999893)
Retinoblastoma  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Ovarian Neoplasms  (Score: 0.985791)
Glioblastoma  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3910D000077192
Disease Name:lung adenocarcinomaAdenocarcinoma of Lung
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin.A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.
Alias:bronchogenic lung adenocarcinoma//nonsmall cell adenocarcinomaAdenocarcinoma of Lung//Lung Adenocarcinomas//Lung Adenocarcinoma//Adenocarcinoma, Lung//Adenocarcinomas, Lung

 

Disease Association Statistics

Total Associated ncRNA Number:656   
More Information
Causal ncRNA Number:386
Network:
Top Causal ncRNAs:
LINC00665  (Score: 1)
LINC00511  (Score: 1)
FAM83A-AS1  (Score: 1)
LINC00665  (Score: 1)
LINC00511  (Score: 1)
FAM83A-AS1  (Score: 1)
CCAT1  (Score: 0.999893)
H19  (Score: 0.999893)
SNHG17  (Score: 0.999893)
LINC00467  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:29510777
Disease Name:Adenocarcinoma of Lung
Sample:(LAD) tissues and cell lines
Dysfunction Pattern:Interaction(FEZF1 )
Validated Method:Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Description:In the present study, we demonstrated that lncRNA forebrain embryonic zinc finger protein 1 (FEZF1) antisense RNA1 (FEZF1-AS1) is markedly upregulated in human lung adenocarcinoma (LAD) tissues and cell lines and is associated with poor prognosis.Further studies revealed that downregulation of FEZF1-AS1 reduced mRNA and protein expression of its sense-cognate gene FEZF1 in LAD cells, and vice versa. Correlation analysis indicated that there was a positive correlation between FEZF1-AS1 and FEZF1 expression in LAD tissues. Additionally, rescue assay confirmed that the function of FEZF1-AS1 in LAD was mediated by FEZF1.
Causality:Yes
Causal Description: Loss of function revealed that deletion of FEZF1-AS1 expression significantly inhibited the LAD cell proliferation, invasion, and migration.
Clinical-realted Application:In the present study, we demonstrated that lncRNA forebrain embryonic zinc finger protein 1 (FEZF1) antisense RNA1 (FEZF1-AS1) is markedly upregulated in human lung adenocarcinoma (LAD) tissues and cell lines and is associated with poor prognosis.