Entry Detail

General Information

Database ID: LDA0000817
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FENDRR
Full Name:FOXF1 adjacent non-coding developmental regulatory RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:FOXF1-AS1|FOXF1AS1|TCONS_00024240|lincFOXF1|onco-lncRNA-21
Chromosome:16
Strand:-
Coordinate:
Start Site(bp):86474525End Site(bp):86508860
External Links:
Ensembl ID:ENSG00000268388
Ensembl Transcript ID:N/A
Entrez Gene:400550.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:34   
More Information
Causal Disease Number:22
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Hepatocellular  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
Cholangiocarcinoma  (Score: 0.731059)
Colonic Neoplasms  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
endometrial endometrioid adenocarcinoma, secretory variant  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:7289
Disease Name:endometrial endometrioid adenocarcinoma, secretory variant
Category:Disease Ontology
Type:Neoplasms
Define:An endometrial adenocarcinoma that is characterized by the presence of confluent, cribriform or villoglandular voluminous glands with glycogen, subnuclear vacuoles (resembles day 17 - 22 endometrium), plus late secretory pattern in uninvolved endometrium.
Alias:

 

Disease Association Statistics

Total Associated ncRNA Number:4   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
FENDRR  (Score: 0.731059)
LncRNA-ZXF1  (Score: 0.731059)
FENDRR  (Score: 0.731059)
LncRNA-ZXF1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//MeRIP//qRT-PCR//RIP//Cell Apoptosis Assay//Cell Proliferation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33692441
Disease Name:endometrial endometrioid adenocarcinoma, secretory variant
Sample:cancerous tissues
Dysfunction Pattern:Regulation(SOX4 )
Validated Method:In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//MeRIP//qRT-PCR//RIP//Cell Apoptosis Assay//Cell Proliferation Assay
Description:The expression level of LncRNA FENDRR was decreased and the N-methyladenosine (m6A) methylation levels of LncRNA FENDRR was elevated in cancerous tissues of EEC patients. LncRNA FENDRR overexpression suppressed cell proliferation and facilitated cell apoptosis in the EEC cell line HEC-1B by reducing the protein level of SRY-related HMG box transcription factor 4 (SOX4).Interference of LncRNA FENDRR reversed the inhibitory effect of sh-YTHDF2 on cell proliferation and the promoting effect of sh-YTHDF2 on cell apoptosis in HEC-1B cells by silencing FENDRR.
Causality:Yes
Causal Description: In vitro experiments demonstrated that YTH domain-containing 2 (YTHDF2), an m6A reader, recognized the abundance of m6A-modified LncRNA FENDRR in EEC cells and promoted its degradation.Finally, in vivo experiments confirmed that overexpression of LncRNA FENDRR retarded the growth of EEC cells.
Clinical-realted Application: