Entry Detail

General Information

Database ID: LDA0000842
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FAT1
Full Name:FAT atypical cadherin 1
Category:LncRNA
Species:Homo sapiens
Synonyms:CDHF7|CDHR8|FAT|ME5|hFat1
Chromosome:4
Strand:-
Coordinate:
Start Site(bp):186587794End Site(bp):186726696
External Links:
Ensembl ID:ENSG00000083857
Ensembl Transcript ID:N/A
Entrez Gene:2195.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D000077277
Disease Name:Esophageal Squamous Cell Carcinoma
Category:MeSH
Type:Neoplasms
Define:A carcinoma that originates usually from cells on the surface of the middle and lower third of the ESOPHAGUS. Tumor cells exhibit typical squamous morphology and form large polypoid lesions. Mutations in RNF6, LZTS1, TGFBR2, DEC1, and WWOX1 genes are associated with this cancer.
Alias:Esophageal Squamous Cell Carcinoma//Oesophageal Squamous Cell Carcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:2730   
More Information
Causal ncRNA Number:360
Network:
Top Causal ncRNAs:
ciRS-7  (Score: 1)
ZNF667-AS1  (Score: 1)
SNHG6  (Score: 1)
ZNF667-AS1  (Score: 1)
BBOX1-AS1  (Score: 1)
SNHG6  (Score: 1)
CASC9  (Score: 1)
ciRS-7  (Score: 1)
CASC9  (Score: 1)
BBOX1-AS1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//RIP//PCR//IP//Invasion Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34185205
Disease Name:Esophageal Squamous Cell Carcinoma
Sample:tumor tissue
Dysfunction Pattern:Interaction(miR-548g)
Validated Method:qRT-PCR//RIP//PCR//IP//Invasion Assay
Description:CircFAT1 expression levels were significantly lower in tumor tissue than in adjacent non-tumorous mucosal tissue (p = 0.01). The expression of miR-548g was upregulated by the downregulation of circFAT1. The overexpression of miR-548g also promoted ESCC cell migration and invasion. Recurrence-free survival (p = 0.02) and cancer-specific survival (p = 0.04) rates were significantly higher in patients with elevated circFAT1 expression levels.
Causality:Yes
Causal Description:The downregulation of circFAT1 expression promoted ESCC cell migration and invasive ability, but not proliferation.
Clinical-realted Application: