Entry Detail

General Information

Database ID: LDA0000844
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FAS-AS1
Full Name:FAS antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:FAS-AS|FASAS|SAF
Chromosome:10
Strand:-
Coordinate:
Start Site(bp):88991422End Site(bp):88992975
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:100302740.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:8   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3908D002289
Disease Name:lung non-small cell carcinomaCarcinoma, Non-Small-Cell Lung
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Alias:NSCLC//Non-small cell lung cancer//non-small cell lung carcinomaCarcinoma, Non-Small-Cell Lung//Carcinoma, Non Small Cell Lung//Carcinomas, Non-Small-Cell Lung//Lung Carcinoma, Non-Small-Cell//Lung Carcinomas, Non-Small-Cell//Non-Small-Cell Lung Carcinomas//Non-Small-Cell Lung Carcinoma//Non Small Cell Lung Carcinoma//Carcinoma, Non-Small Cell Lung//Non-Small Cell Lung Carcinoma//Non-Small Cell Lung Cancer//Nonsmall Cell Lung Cancer

 

Disease Association Statistics

Total Associated ncRNA Number:1090   
More Information
Causal ncRNA Number:936
Network:
Top Causal ncRNAs:
AFAP1-AS1  (Score: 1)
FEZF1-AS1  (Score: 1)
BCYRN1  (Score: 1)
GAS5  (Score: 1)
MALAT1  (Score: 1)
MAGI2-AS3  (Score: 1)
AWPPH  (Score: 1)
DANCR  (Score: 1)
hsa_circ_0007385  (Score: 1)
hsa_circ_0074027  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32329854
Disease Name:Carcinoma, Non-Small-Cell Lung
Sample:NSCLC cells
Dysfunction Pattern:regulation[regulating miR-19a-5p]
Validated Method:qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Description:FAS-AS1 was remarkably down-regulated in NSCLC cells.FAS-AS1 suppressed cell proliferation, migration, and invasion by sponging miR-19a-5p in NSCLC, indicating that FAS-AS1 might be a potential biomarker and therapeutic target for NSCLC.
Causality:Yes
Causal Description: FAS-AS1 inhibited cell proliferation, migration, and invasion in NSCLC cells.
Clinical-realted Application:

[2] PubMed ID:30866866
Disease Name:Carcinoma, Non-Small-Cell Lung
Sample:NSCLC tissues
Dysfunction Pattern:Expression[lower expressed]
Validated Method:qRT-PCR
Description:FAS-AS1 was significantly down-regulated in NSCLC tissues obtained from both males and females subjects compared with the corresponding ANCTs (REx = - 4.12 and - 3.14, P = 0.015 and 0.033 respectively).
Causality:No
Causal Description:
Clinical-realted Application: