Entry Detail

General Information

Database ID: LDA0000848
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:FAM88C
Full Name:family with sequence similarity 88 member C
Category:LncRNA
Species:Homo sapiens
Synonyms:Lnc-PPRL
Chromosome:9
Strand:-
Coordinate:
Start Site(bp):62374481End Site(bp):62376870
External Links:
Ensembl ID:ENSG00000204802
Ensembl Transcript ID:N/A
Entrez Gene:102724238.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Pterygium  (Score: 0.731059)
Pterygium  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0002116D011625
Disease Name:pterygiumPterygium
Category:Disease OntologyMeSH
Type:Eye Diseases
Define:A corneal disease that is characterized by a triangular tissue growth located_in cornea of the eye that is the result of collagen degeneration and fibrovascular proliferation.An abnormal triangular fold of membrane in the interpalpebral fissure, extending from the conjunctiva to the cornea, being immovably united to the cornea at its apex, firmly attached to the sclera throughout its middle portion, and merged with the conjunctiva at its base. (Dorland, 27th ed)
Alias:surfer's eyePterygium//Pterygiums

 

Disease Association Statistics

Total Associated ncRNA Number:596   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
FOXD2-AS1  (Score: 0.731059)
FAM88C  (Score: 0.731059)
FOXD2-AS1  (Score: 0.731059)
FAM88C  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transwell Assay//migration assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//IF
Weak Evidence:

 

Reference

[1] PubMed ID:35304111
Disease Name:Pterygium
Sample:pterygium tissues
Dysfunction Pattern:Interaction( PI3K/PDK1 pathway and Akt/mTOR signaling pathway )
Validated Method:Western Blot//IF//migration assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//Transwell Assay
Description:Notably, we identified a novel lncRNA, LOC102724238, which we named pterygium positively-related lncRNA (lnc-PPRL), was up-regulated in pterygium. Further study of underlying mechanisms demonstrated that lnc-PPRL may exert its biological effect by activating canonical PI3K/PDK1 pathway, and subsequently promoting the activation of Akt/mTOR signaling pathway and its downstream effectors.Interestingly, lnc-PPRL was also proved to influence YAP nuclear localization.
Causality:Yes
Causal Description: Lnc-PPRL showed to be preferentially accumulated in cytoplasm, and it can promote cell proliferation, migration and invasion of human pterygium epithelium cells (hPECs).
Clinical-realted Application: