Entry Detail


General Information

Database ID: LDA0000856
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:H19
Full Name:H19, imprinted maternally expressed transcript
Category:LncRNA
Species:Mus musculus
Synonyms:EyeLinc6
Chromosome:7
Strand:-
Coordinate:
Start Site(bp):142129267End Site(bp):142131883
External Links:
Ensembl ID:ENSMUSG00000000031
Ensembl Transcript ID:N/A
Entrez Gene:14955.0
NONCODE ID:N/A
RefSeq Accession:NR_130973.1

 

ncRNA Association Statistics

Total Associated Disease Number:214   
More Information
Causal Disease Number:122
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Glioma  (Score: 1)
Glioma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:6713D020521
Disease Name:cerebrovascular diseaseStroke
Category:Disease OntologyMeSH
Type:Nervous System Diseases
Define:An vascular disease that is characterized by dysfunction of the blood vessels supplying the brain.A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Alias:CVA//cerebrovascular disorder//strokeStroke//Strokes//Cerebrovascular Accident//Cerebrovascular Accidents//CVA (Cerebrovascular Accident)//CVAs (Cerebrovascular Accident)//Cerebrovascular Apoplexy//Apoplexy, Cerebrovascular//Vascular Accident, Brain//Brain Vascular Accident//Brain Vascular Accidents//Vascular Accidents, Brain//Cerebrovascular Stroke//Cerebrovascular Strokes//Stroke, Cerebrovascular//Strokes, Cerebrovascular//Apoplexy//Cerebral Stroke//Cerebral Strokes//Stroke, Cerebral//Strokes, Cerebral//Stroke, Acute//Acute Stroke//Acute Strokes//Strokes, Acute//Cerebrovascular Accident, Acute//Acute Cerebrovascular Accident//Acute Cerebrovascular Accidents//Cerebrovascular Accidents, Acute

 

Disease Association Statistics

Total Associated ncRNA Number:18   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
H19  (Score: 0.731059)
H19  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Transfection//Tunel//Flow Cytometry//RIP//qRT-PCR//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31170091
Disease Name:Stroke
Sample:blood
Dysfunction Pattern:Regulation[H19-miR-19a-Id2 axis]
Validated Method:RNA Pull-Down//Western Blot//Transfection//Tunel//Flow Cytometry//RIP//qRT-PCR//Luciferase Report Assay
Description:This study found that H19 levels were elevated in the serum of stroke patients, as well as in the ischemic penumbra of rats with middle cerebral artery occlusion/reperfusion (MCAO/R) injury and neuronal cells with oxygen glucose deprivation (OGD). Lastly, with gain and loss of function studies, dual luciferase reported assay, RNA immunoprecipitation (RIP) and pull-down experiments, we demonstrated the dual competitive interaction of miR-19a with H19 and the 3'-UTR of Id2 mRNA, resulting in the identification of the H19-miR-19a-Id2 axis. With biological studies, we also revealed that H19-miR-19a-Id2 axis modulated hypoxia induced neuronal apoptosis. This study demonstrates that the identified H19-miR-19a-Id2 axis plays a critical role in hypoxia induced neuronal apoptosis, and blocking this axis may serve as a novel therapeutic strategy for ischemic brain injury.
Causality:Yes
Causal Description:Further, knockdown of H19 with siRNA alleviated cell apoptosis in OGD neuronal cells, and inhibition of H19 in MCAO/R rats significantly decreased neurological deficit, brain infarct volume and neuronal apoptosis.
Clinical-realted Application: