Entry Detail

General Information

Database ID: LDA0000862
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:H19
Full Name:H19, imprinted maternally expressed transcript
Category:LncRNA
Species:Mus musculus
Synonyms:EyeLinc6
Chromosome:7
Strand:-
Coordinate:
Start Site(bp):142129267End Site(bp):142131883
External Links:
Ensembl ID:ENSMUSG00000000031
Ensembl Transcript ID:N/A
Entrez Gene:14955.0
NONCODE ID:N/A
RefSeq Accession:NR_130973.1

 

ncRNA Association Statistics

Total Associated Disease Number:214   
More Information
Causal Disease Number:122
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Glioma  (Score: 1)
Glioma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0080522D065646
Disease Name:thyroid gland anaplastic carcinomaThyroid Carcinoma, Anaplastic
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A thyroid gland carcinoma that is composed of undifferentiated cells.An aggressive THYROID GLAND malignancy which generally occurs in IODINE-deficient areas in people with previous thyroid pathology such as GOITER. It is associated with CELL DEDIFFERENTIATION of THYROID CARCINOMA (e.g., FOLLICULAR THYROID CARCINOMA; PAPILLARY THYROID CANCER). Typical initial presentation is a rapidly growing neck mass which upon metastasis is associated with DYSPHAGIA; NECK PAIN; bone pain; DYSPNEA; and NEUROLOGIC DEFICITS.
Alias:anaplastic thyroid carcinomaThyroid Carcinoma, Anaplastic//Anaplastic Thyroid Carcinoma//Anaplastic Thyroid Carcinomas//Carcinoma, Anaplastic Thyroid//Carcinomas, Anaplastic Thyroid//Thyroid Carcinomas, Anaplastic//Thyroid Cancer, Anaplastic//Anaplastic Thyroid Cancer//Anaplastic Thyroid Cancers//Cancer, Anaplastic Thyroid//Cancers, Anaplastic Thyroid//Thyroid Cancers, Anaplastic

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
UCA1  (Score: 0.985791)
UCA1  (Score: 0.985791)
HOTAIRM1  (Score: 0.731059)
HCP5  (Score: 0.731059)
H19  (Score: 0.731059)
AFAP-AS1  (Score: 0.731059)
MANCR  (Score: 0.731059)
HOTAIRM1  (Score: 0.731059)
HCP5  (Score: 0.731059)
H19  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//migration assay//cell invasion assay//Colony Formation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31299871
Disease Name:Thyroid Carcinoma, Anaplastic
Sample:thyroid tissues
Dysfunction Pattern:Expression[highly expressed]
Validated Method:CCK8//qRT-PCR//migration assay//cell invasion assay//Colony Formation Assay
Description:Expression of H19 was detected in 19 ATC and 19 normal thyroid tissues by real-time quantitative polymerase chain reaction.
Causality:Yes
Causal Description:H19 inhibited proliferation, migration, and invasion and induced apoptosis in 8505C cells in vitro and inhibited tumorigenesis and metastasis in vivo.
Clinical-realted Application: