Entry Detail

General Information

Database ID: LDA0000864
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:H19
Full Name:H19, imprinted maternally expressed transcript
Category:LncRNA
Species:Mus musculus
Synonyms:EyeLinc6
Chromosome:7
Strand:-
Coordinate:
Start Site(bp):142129267End Site(bp):142131883
External Links:
Ensembl ID:ENSMUSG00000000031
Ensembl Transcript ID:N/A
Entrez Gene:14955.0
NONCODE ID:N/A
RefSeq Accession:NR_130973.1

 

ncRNA Association Statistics

Total Associated Disease Number:214   
More Information
Causal Disease Number:122
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Glioma  (Score: 1)
Glioma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D012128
Disease Name:Respiratory Distress Syndrome
Category:MeSH
Type:Respiratory Tract Diseases
Define:A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.
Alias:Respiratory Distress Syndrome//Distress Syndrome, Respiratory//Distress Syndromes, Respiratory//Respiratory Distress Syndromes//Syndrome, Respiratory Distress//Shock Lung//Lung, Shock//Respiratory Distress Syndrome, Acute//Acute Respiratory Distress Syndrome//ARDS, Human//Human ARDS//Respiratory Distress Syndrome, Pediatric//Pediatric Respiratory Distress Syndrome//Respiratory Distress Syndrome, Adult//Adult Respiratory Distress Syndrome

 

Disease Association Statistics

Total Associated ncRNA Number:6   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
H19  (Score: 0.731059)
SNHG5  (Score: 0.731059)
H19  (Score: 0.731059)
SNHG5  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//H&E Staining//IHC
Weak Evidence:

 

Reference

[1] PubMed ID:33629893
Disease Name:Respiratory Distress Syndrome
Sample:MH-S & MLE-12
Dysfunction Pattern:Interaction(microRNA-423-5p/FOXA1 axis)
Validated Method:In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//H&E Staining//IHC
Description:The expression of H19 and FOXA1 was significantly up-regulated, while the expression of miR-423-5p was down-regulated in LPS-induced ARDS rats. Silencing of H19 decreased the mRNA expression of TNF-α, IL-1β, IL-6, MCP-1, and VEGF, the contents of TNF-α, IL-1β, IL-6, and VEGF in BALF, and histology score in LPS-induced ARDS rats. H19 knockdown also reduced the fibrosis scores and the protein expression of vimentin and α-SMA, and elevated the protein expression of E-cadherin in LPS-induced ARDS rats. Furthermore, silencing of miR-423-5p and overexpression of FOXA1 reversed the inhibitory effects of si-H19 on the inflammation and fibrosis of LPS-induced MH-S cells.
Causality:Yes
Causal Description:Silencing of H19 decreased the mRNA expression of TNF-α, IL-1β, IL-6, MCP-1, and VEGF, the contents of TNF-α, IL-1β, IL-6, and VEGF in BALF, and histology score in LPS-induced ARDS rats. H19 knockdown also reduced the fibrosis scores and the protein expression of vimentin and α-SMA, and elevated the protein expression of E-cadherin in LPS-induced ARDS rats. Furthermore, silencing of miR-423-5p and overexpression of FOXA1 reversed the inhibitory effects of si-H19 on the inflammation and fibrosis of LPS-induced MH-S cells.
Clinical-realted Application: