Entry Detail

General Information

Database ID: LDA0000868
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:H19
Full Name:H19, imprinted maternally expressed transcript
Category:LncRNA
Species:Mus musculus
Synonyms:EyeLinc6
Chromosome:7
Strand:-
Coordinate:
Start Site(bp):142129267End Site(bp):142131883
External Links:
Ensembl ID:ENSMUSG00000000031
Ensembl Transcript ID:N/A
Entrez Gene:14955.0
NONCODE ID:N/A
RefSeq Accession:NR_130973.1

 

ncRNA Association Statistics

Total Associated Disease Number:214   
More Information
Causal Disease Number:122
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Glioma  (Score: 1)
Glioma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D000080443
Disease Name:Diffuse Intrinsic Pontine Glioma
Category:MeSH
Type:Neoplasms
Define:A rare, aggressive brain tumor that forms in the GLIAL CELLS in the PONS.
Alias:Diffuse Intrinsic Pontine Glioma//DIPG Brain Tumors//Brain Tumor, DIPG//DIPG Brain Tumor//DIPG, Diffuse Intrinsic Pontine Glioma

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
H19  (Score: 0.731059)
H19  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Cell Proliferation Assay//Transfection//Wound Healing Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34502082
Disease Name:Diffuse Intrinsic Pontine Glioma
Sample:DIPG Tissue
Dysfunction Pattern:Interaction( let-7 microRNAs)
Validated Method:Transfection//Wound Healing Assay//RNA-seq//Cell Proliferation Assay//Bioinformatics Analysis
Description:We found that H19 expression was higher in DIPG vs. normal brain tissue and other pedHGGs. Mechanistically, H19 buffers let-7 microRNAs, resulting in the up-regulation of oncogenic let-7 target (e.g., SULF2 and OSMR)
Causality:Yes
Causal Description:H19 knockdown resulted in decreased cell proliferation and survival in DIPG cells. 
Clinical-realted Application: