Entry Detail

General Information

Database ID: LDA0000904
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:GNAS-AS1
Full Name:GNAS antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:GNAS-AS|GNAS1AS|GNASAS|NCRNA00075|NESP-AS|NESPAS|SANG
Chromosome:20
Strand:-
Coordinate:
Start Site(bp):58818918End Site(bp):58850903
External Links:
Ensembl ID:ENSG00000235590
Ensembl Transcript ID:N/A
Entrez Gene:149775.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:14   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Osteoarthritis  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Nasopharyngeal carcinoma  (Score: 0.731059)
Keloid  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Osteoarthritis  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Nasopharyngeal carcinoma  (Score: 0.731059)
Keloid  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8398D010003
Disease Name:osteoarthritisOsteoarthritis
Category:Disease OntologyMeSH
Type:Musculoskeletal Diseases
Define:An arthritis that has_material_basis_in worn out cartilage located_in joint.A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
Alias:Osteoarthrosis and allied disorder//degenerative arthritis//degenerative joint disease//hypertrophic arthritis//osteoarthrosisOsteoarthritis//Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans

 

Disease Association Statistics

Total Associated ncRNA Number:784   
More Information
Causal ncRNA Number:154
Network:
Top Causal ncRNAs:
HOTAIR  (Score: 0.999893)
HOTAIR  (Score: 0.999893)
MCM3AP-AS1  (Score: 0.985791)
hsa_circ_0005567  (Score: 0.985791)
hsa_circ_0032131  (Score: 0.985791)
CASC2  (Score: 0.985791)
PVT1  (Score: 0.985791)
XIST  (Score: 0.985791)
hsa_circ_0032131  (Score: 0.985791)
PVT1  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:28805067
Disease Name:Osteoarthritis
Sample:cartilage tissues
Dysfunction Pattern:Interaction[ACSL6 ]
Validated Method:qRT-PCR//Western Blot
Description:Highly elevated levels of Nespas and Acyl-CoA synthetase 6 (ACSL6) were observed in OA patients.Overall, we suggest that elevated Nespas level in OA are associated with OA pathogenesis by suppressing miRs targeting ACSL6 and subsequent ACSL6 upregulation.
Causality:Yes
Causal Description:Both Nespas overexpression and ACSL6 upregulation into human chondrocytes induced typical OA characteristics, such as downregulation of type II collagen; upregulation of type I collagen, metalloproteinase 13, and caspase-1 and -3; and dysfunction of mitochondria and peroxisome.
Clinical-realted Application: