Entry Detail

General Information

Database ID: LDA0000911
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:H19
Full Name:H19, imprinted maternally expressed transcript
Category:LncRNA
Species:Mus musculus
Synonyms:EyeLinc6
Chromosome:7
Strand:-
Coordinate:
Start Site(bp):142129267End Site(bp):142131883
External Links:
Ensembl ID:ENSMUSG00000000031
Ensembl Transcript ID:N/A
Entrez Gene:14955.0
NONCODE ID:N/A
RefSeq Accession:NR_130973.1

 

ncRNA Association Statistics

Total Associated Disease Number:214   
More Information
Causal Disease Number:122
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Glioma  (Score: 1)
Glioma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D058186
Disease Name:Acute Kidney Injury
Category:MeSH
Type:Urogenital Diseases
Define:Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
Alias:Acute Kidney Injury//Acute Kidney Injuries//Kidney Injuries, Acute//Kidney Injury, Acute//Acute Renal Injury//Acute Renal Injuries//Renal Injuries, Acute//Renal Injury, Acute//Renal Insufficiency, Acute//Acute Renal Insufficiencies//Renal Insufficiencies, Acute//Acute Renal Insufficiency//Kidney Insufficiency, Acute//Acute Kidney Insufficiencies//Kidney Insufficiencies, Acute//Acute Kidney Insufficiency//Kidney Failure, Acute//Acute Kidney Failures//Kidney Failures, Acute//Acute Renal Failure//Acute Renal Failures//Renal Failures, Acute//Renal Failure, Acute//Acute Kidney Failure

 

Disease Association Statistics

Total Associated ncRNA Number:30   
More Information
Causal ncRNA Number:30
Network:
Top Causal ncRNAs:
NEAT1  (Score: 0.985791)
MALAT1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
MALAT1  (Score: 0.985791)
PVT1  (Score: 0.731059)
Kcnq1ot1  (Score: 0.731059)
H19  (Score: 0.731059)
CASC2  (Score: 0.731059)
SNHG14  (Score: 0.731059)
hsa_circ_0020339  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//qPCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//IHC//EdU Staining//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:33478972
Disease Name:Acute Kidney Injury
Sample:murine ischemic kidney tissue, Ecs, TECs
Dysfunction Pattern:Interaction(miR-30a-5p)
Validated Method:In Vivo Experiment//Western Blot//Transfection//qPCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay//IHC//EdU Staining//ChIP
Description:H19 is upregulated in kidney biopsies of patients with AKI, in murine ischemic kidney tissue, and in cultured and ex vivo sorted hypoxic endothelial cells (ECs) and tubular epithelial cells (TECs). Sponging of miR-30a-5p mediated the effects, which, in turn, led to target regulation of Dll4, ATG5, and Snai1.
Causality:Yes
Causal Description: H19 overexpression promotes angiogenesis in vitro and in vivo. In vivo, transient AAV2-mediated H19 overexpression significantly improved kidney function, reduced apoptosis, and reduced inflammation, as well as preserving capillary density and tubular epithelial integrity.
Clinical-realted Application: