Entry Detail

General Information

Database ID: LDA0000912
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:H19
Full Name:H19, imprinted maternally expressed transcript
Category:LncRNA
Species:Mus musculus
Synonyms:EyeLinc6
Chromosome:7
Strand:-
Coordinate:
Start Site(bp):142129267End Site(bp):142131883
External Links:
Ensembl ID:ENSMUSG00000000031
Ensembl Transcript ID:N/A
Entrez Gene:14955.0
NONCODE ID:N/A
RefSeq Accession:NR_130973.1

 

ncRNA Association Statistics

Total Associated Disease Number:214   
More Information
Causal Disease Number:122
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Glioma  (Score: 1)
Glioma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:552D011014
Disease Name:pneumoniaPneumonia
Category:Disease OntologyMeSH
Type:Infections
Define:A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. It is accompanied by fever, chills, cough, and difficulty in breathing.Infection of the lung often accompanied by inflammation.
Alias:acute pneumoniaPneumonia//Pneumonias//Lobar Pneumonia//Lobar Pneumonias//Pneumonias, Lobar//Pneumonia, Lobar//Experimental Lung Inflammation//Experimental Lung Inflammations//Inflammation, Experimental Lung//Lung Inflammation, Experimental//Lung Inflammations, Experimental//Pneumonitis//Pneumonitides//Pulmonary Inflammation//Inflammation, Pulmonary//Inflammations, Pulmonary//Pulmonary Inflammations//Lung Inflammation//Inflammation, Lung//Inflammations, Lung//Lung Inflammations

 

Disease Association Statistics

Total Associated ncRNA Number:12   
More Information
Causal ncRNA Number:10
Network:
Top Causal ncRNAs:
H19  (Score: 0.985791)
H19  (Score: 0.985791)
CASC9  (Score: 0.731059)
SNHG16  (Score: 0.731059)
hsa_circ_0026579  (Score: 0.731059)
hsa_circ_0038467  (Score: 0.731059)
CASC9  (Score: 0.731059)
SNHG16  (Score: 0.731059)
hsa_circ_0026579  (Score: 0.731059)
hsa_circ_0038467  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//Tunel//qRT-PCR//MTT//Luciferase Report Assay//ELISA//IF
Weak Evidence:

 

Reference

[1] PubMed ID:34786066
Disease Name:Pneumonia
Sample:WL-38 cell
Dysfunction Pattern:Interaction(miR-22-3p/NLRP3 axis)
Validated Method:Western Blot//Transfection//Tunel//qRT-PCR//MTT//Luciferase Report Assay//ELISA//Bioinformatics Analysis//IF
Description:In the LPS induced pneumonia model, LncRNA H19 silences inhibited LPS-induced WL-38 cell pyroptosis, and LncRNA H19 overexpression promotes LPS-induced WL-38 cell pyroptosis. Also, LncRNA H19 acts as a sponge of miR-22-3p, which targets NLRP3, and NLRP3 attenuates the effect of LncRNA H19 silencing on LPS-induced WL-38 cell pyroptosis.
Causality:Yes
Causal Description:In the LPS induced pneumonia model, LncRNA H19 silences inhibited LPS-induced WL-38 cell pyroptosis, and LncRNA H19 overexpression promotes LPS-induced WL-38 cell pyroptosis. Also, LncRNA H19 acts as a sponge of miR-22-3p, which targets NLRP3, and NLRP3 attenuates the effect of LncRNA H19 silencing on LPS-induced WL-38 cell pyroptosis.
Clinical-realted Application:

[2] PubMed ID:35392782
Disease Name:Pneumonia
Sample:peripheral blood of patients with pneumonia, WI-38 cells
Dysfunction Pattern:Interaction(miR-140-5p/TLR4 Axis)
Validated Method:qRT-PCR//ELISA//MTT
Description:LncRNA H19 and TLR4 were up-regulated, while miR-140-5p was downregulated in peripheral blood of patients with pneumonia and LPS-treated WI-38 cells compared with their controls. H19 targeted miR-140-5p and it inversely regulated miR-140- 5p expression. MiR-140-5p targeted TLR4 and it inversely regulated TLR4 expression. H19 positively regulated TLR4 expression. Moreover, inhibition of miR-140-5p or overexpression of TLR4 reversed the effects of H19 silencing on cell viability, inflammation, and apoptosis in LPS-induced WI-38 cells.
Causality:Yes
Causal Description:Silencing of H19 or miR-140-5p mimics facilitated cell viability, whereas repressed apoptosis and reduced content of TNF-α, IL-6, and IL-1β in LPS-induced WI-38 cells.
Clinical-realted Application: