Entry Detail

General Information

Database ID: LDA0000933
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HAND2-AS1
Full Name:HAND2 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:DEIN|NBLA00301|UPH
Chromosome:4
Strand:+
Coordinate:
Start Site(bp):173528600End Site(bp):173591255
External Links:
Ensembl ID:ENSG00000237125
Ensembl Transcript ID:N/A
Entrez Gene:79804.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:42   
More Information
Causal Disease Number:36
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Uterine Cervical Neoplasms  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Urinary Bladder Neoplasms  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Urinary Bladder Neoplasms  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3717
Disease Name:gastric adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A stomach carcinoma that derives_from epithelial cells of glandular origin.
Alias:adenocarcinoma of stomach//stomach adenocarcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:40   
More Information
Causal ncRNA Number:28
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.985791)
MALAT1  (Score: 0.985791)
PMS2P2  (Score: 0.731059)
ITGB1-DT  (Score: 0.731059)
FOXCUT  (Score: 0.731059)
HAND2-AS1  (Score: 0.731059)
DIRC1  (Score: 0.731059)
RP1-163G9.1  (Score: 0.731059)
TM4SF1-AS1  (Score: 0.731059)
TRPM2-AS  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Western Blot//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32431548
Disease Name:gastric adenocarcinoma
Sample:GA tissues and cells
Dysfunction Pattern:regulation[miR-184/HIF3A signaling]
Validated Method:qRT-PCR//Luciferase Report Assay//Transwell Assay//Western Blot
Description:The HAND2-AS1 and HIF3A expressions were down-regulated and miR-184 expression was up-regulated in GA tissues and cells. LncRNA HAND2-AS1 could inhibit GA cell proliferation, migration and invasion abilities and glycolytic process induced by hypoxia through miR-184/HIF3A signaling.
Causality:Yes
Causal Description: In addition, HAND2-AS1 rescued enhanced AGS cell proliferation, cell migration, cell invasion abilities and glycolytic process caused by hypoxia via miR-184/HIF3A.
Clinical-realted Application: