Entry Detail

General Information

Database ID: LDA0000934
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HAND2-AS1
Full Name:HAND2 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:DEIN|NBLA00301|UPH
Chromosome:4
Strand:+
Coordinate:
Start Site(bp):173528600End Site(bp):173591255
External Links:
Ensembl ID:ENSG00000237125
Ensembl Transcript ID:N/A
Entrez Gene:79804.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:42   
More Information
Causal Disease Number:36
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Uterine Cervical Neoplasms  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Urinary Bladder Neoplasms  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Urinary Bladder Neoplasms  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3748
Disease Name:esophagus squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:An esophageal carcinoma that derives_from epithelial squamous cells located_in the esophagus.
Alias:SCC of esophagus//SCC of oesophagus//oesophagus squamous cell carcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
HAND2-AS1  (Score: 0.731059)
HAND2-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:30520131
Disease Name:esophagus squamous cell carcinoma
Sample:ESCC tissue
Dysfunction Pattern:Interaction[regulating microRNA-21]
Validated Method:CCK8//qRT-PCR//Transwell Assay
Description:In this study, we found that lncRNA HAND2-AS1 was Expression[down-expression]regulated, while microRNA-21 ( miRNA-21) was Expression[Expression[up-expression]-expression]regulated in tumor tissues than in adjacent healthy tissues of ESCC patients.Expression levels of lncRNA HAND2-AS1 and miRNA-21 were significantly and inversely correlated in tumor tissues but not in healthy tissues.miRNA-21 overexpression failed to affect lncRNA HAND2-AS1 expression but significantly attenuated the inhibitory effect of lncRNA HAND2-AS1 overexpression on cancer cell proliferation, migration, and invasion.
Causality:Yes
Causal Description:lncRNA HAND2-AS1 overexpression resulted in Expression[down-expression]regulation of miRNA-21 in cells of ESCC cell lines and inhibited cell proliferation, migration, and invasion.
Clinical-realted Application: