Entry Detail

General Information

Database ID: LDA0000935
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HAND2-AS1
Full Name:HAND2 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:DEIN|NBLA00301|UPH
Chromosome:4
Strand:+
Coordinate:
Start Site(bp):173528600End Site(bp):173591255
External Links:
Ensembl ID:ENSG00000237125
Ensembl Transcript ID:N/A
Entrez Gene:79804.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:42   
More Information
Causal Disease Number:36
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Uterine Cervical Neoplasms  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Urinary Bladder Neoplasms  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Urinary Bladder Neoplasms  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3744
Disease Name:cervical squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A cervix carcinoma that has_material_basis_in squamous cells of the cervix.
Alias:squamous cell carcinoma of cervix//squamous cell carcinoma of the Cervix Uteri

 

Disease Association Statistics

Total Associated ncRNA Number:52   
More Information
Causal ncRNA Number:50
Network:
Top Causal ncRNAs:
MCM3AP-AS1  (Score: 0.985791)
MCM3AP-AS1  (Score: 0.985791)
MAGI2-AS3  (Score: 0.985791)
MAGI2-AS3  (Score: 0.985791)
SLC16A1-AS1  (Score: 0.731059)
GATA6-AS  (Score: 0.731059)
BLACAT1  (Score: 0.731059)
CASC9-1  (Score: 0.731059)
DGUOK-AS1  (Score: 0.731059)
MACC1-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//qPCR//CCK8//ELISA//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31555362
Disease Name:cervical squamous cell carcinoma
Sample:blood
Dysfunction Pattern:Interaction[downregulating ROCK1]
Validated Method:Western Blot//qPCR//CCK8//ELISA//Transwell Assay
Description:The current study revealed that lncRNA HAND2-AS1 was downregulated, while Rho-associated protein kinase 1 (ROCK1) was upregulated in serum of human papillomavirus (HPV)-positive and -negative patients with CSCC compared with healthy controls.Additionally, lncRNA HAND2-AS1 overexpression led to reduced expression levels of ROCK1 in HPV-positive and -negative human CSCC cell lines but not in normal cervical cell lines. ROCK1 overexpression did not significantly affect the expression of lncRNA HAND2-AS1 in all the cell lines investigated. lncRNA HAND2-AS1 overexpression inhibited, while ROCK1 overexpression promoted the proliferation, migration and invasion of HPV-positive and -negative human CSCC cell lines but not normal cervical cell lines. ROCK1 overexpression attenuated the effects of lncRNA HAND2-AS1 overexpression on cancer cell proliferation, migration and invasion. lncRNA HAND2-AS1 may inhibit cancer cell proliferation, migration and invasion by downregulating ROCK1 in HPV-positive and -negative CSCC.
Causality:Yes
Causal Description: lncRNA HAND2-AS1 overexpression inhibited, while ROCK1 overexpression promoted the proliferation, migration and invasion of HPV-positive and -negative human CSCC cell lines but not normal cervical cell lines.
Clinical-realted Application: