Entry Detail

General Information

Database ID: LDA0000945
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HAGLROS
Full Name:HAGLR opposite strand lncRNA
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:2
Strand:+
Coordinate:
Start Site(bp):176178166End Site(bp):176179009
External Links:
Ensembl ID:ENSG00000226363
Ensembl Transcript ID:N/A
Entrez Gene:102800310.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:18
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Esophageal Neoplasms  (Score: 0.731059)
Lymphoma, Large B-Cell, Diffuse  (Score: 0.731059)
lung carcinoma  (Score: 0.731059)
Wilms Tumor  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2154D009396
Disease Name:nephroblastomaWilms Tumor
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A kidney cancer that affects the kidneys and typically located_in children.A malignant kidney tumor, caused by the uncontrolled multiplication of renal stem (blastemal), stromal (STROMAL CELLS), and epithelial (EPITHELIAL CELLS) elements. However, not all three are present in every case. Several genes or chromosomal areas have been associated with Wilms tumor which is usually found in childhood as a firm lump in a child's side or ABDOMEN.
Alias:adult nephroblastomaWilms Tumor//Tumor, Wilms//Wilms' Tumor//Tumor, Wilms'//Wilm Tumor//Wilm's Tumor//Wilms Tumor 1//Nephroblastoma//Nephroblastomas//Bilateral Wilms Tumor//Tumor, Bilateral Wilms//Wilms Tumor, Bilateral

 

Disease Association Statistics

Total Associated ncRNA Number:36   
More Information
Causal ncRNA Number:34
Network:
Top Causal ncRNAs:
XIST  (Score: 0.985791)
XIST  (Score: 0.985791)
OSTM1-AS1  (Score: 0.731059)
SOX21-AS1  (Score: 0.731059)
circNCKAP1  (Score: 0.731059)
CRNDE  (Score: 0.731059)
H19  (Score: 0.731059)
HAGLROS  (Score: 0.731059)
hsa_circ_0093741  (Score: 0.731059)
DLEU2  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay//Transwell Assay//IF
Weak Evidence:

 

Reference

[1] PubMed ID:35358010
Disease Name:Wilms Tumor
Sample:nephroblastoma cell lines
Dysfunction Pattern:Expression(highly expressed)
Validated Method:Western Blot//Transfection//Wound Healing Assay//qRT-PCR//IF//Cell Apoptosis Assay//Cell Proliferation Assay//Transwell Assay
Description:Experiment results showed that HAGLROS expressed highly in nephroblastoma cell lines.
Causality:Yes
Causal Description: HAGLROS knockdown prevented cells from proliferating, and also showed suppressive impact on migration and invasion in HFWT cells. In addition, knockdown of HAGLROS showed a facilitative effect on apoptosis and an inhibitory effect on autophagy. Stimulation of autophagy alleviated HAGLROS silencing-induced apoptosis, while inhibition of autophagy reversed the effect in nephroblastoma cells.
Clinical-realted Application: