Entry Detail

General Information

Database ID: LDA0000949
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HAS2-AS1
Full Name:HAS2 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:HAS2-AS|HAS2AS|HASNT|NCRNA00077
Chromosome:8
Strand:+
Coordinate:
Start Site(bp):121639346End Site(bp):121645325
External Links:
Ensembl ID:ENSG00000248690
Ensembl Transcript ID:N/A
Entrez Gene:594842.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
Glioma  (Score: 0.985791)
Glioma  (Score: 0.985791)
Breast Neoplasms  (Score: 0.731059)
Carcinoma, Ovarian Epithelial  (Score: 0.731059)
Glioblastoma  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Carcinoma, Ovarian Epithelial  (Score: 0.731059)
Glioblastoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D000077216
Disease Name:Carcinoma, Ovarian Epithelial
Category:MeSH
Type:Neoplasms
Define:A malignant neoplasm that originates in cells on the surface EPITHELIUM of the ovary and is the most common form of ovarian cancer. There are five histologic subtypes: papillary serous, endometrioid, mucinous, clear cell, and transitional cell. Mutations in BRCA1, OPCML, PRKN, PIK3CA, AKT1, CTNNB1, RRAS2, and CDH1 genes are associated with this cancer.
Alias:Carcinoma, Ovarian Epithelial//Epithelial Carcinoma, Ovarian//Ovarian Epithelial Carcinomas//Epithelial Ovarian Cancer//Ovarian Epithelial Cancer//Cancer, Ovarian Epithelial//Epithelial Cancer, Ovarian//Ovarian Epithelial Cancers//Ovarian Cancer, Epithelial//Cancer, Epithelial Ovarian//Epithelial Ovarian Cancers//Ovarian Epithelial Carcinoma//Epithelial Ovarian Carcinoma//Carcinoma, Epithelial Ovarian//Epithelial Ovarian Carcinomas//Ovarian Carcinoma, Epithelial

 

Disease Association Statistics

Total Associated ncRNA Number:102   
More Information
Causal ncRNA Number:80
Network:
Top Causal ncRNAs:
HIF1A-AS2  (Score: 0.985791)
HIF1A-AS2  (Score: 0.985791)
circN4BP2L2  (Score: 0.985791)
circBNC2  (Score: 0.985791)
circBNC2  (Score: 0.985791)
circN4BP2L2  (Score: 0.985791)
hsa_circ_0072995  (Score: 0.731059)
circATP2B4  (Score: 0.731059)
HOXB-AS3  (Score: 0.731059)
circRHOBTB3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:31082772
Disease Name:Carcinoma, Ovarian Epithelial
Sample:EOC tissue,cell lines
Dysfunction Pattern:Regulation[ miR-466/RUNX2 axis]
Validated Method:ChIP//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay
Description:In the cells and tissue of EOC, HAS2-AS1 expression was markedly up-regulated.Mechanical investigation found that HAS2-AS1 could relive the RUNX2 protein expression via sponging the miR-466, acting as miRNA sponge. In conclusion, this finding suggests the CREB1/HAS2-AS1/miR-466/RUNX2 axis in the in the EOC tumorigenesis, providing the novel insight for the molecular mechanism of EOC.
Causality:Yes
Causal Description:Functionally, HAS2-AS1 knockdown suppressed the proliferation, invasion and tumor growth of EOC cells in vitro and in vivo.
Clinical-realted Application:Besides, the overexpression of HAS2-AS1 indicated the poor clinical outcome of EOC patients.