Entry Detail

General Information

Database ID: LDA0000950
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HAS2-AS1
Full Name:HAS2 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:HAS2-AS|HAS2AS|HASNT|NCRNA00077
Chromosome:8
Strand:+
Coordinate:
Start Site(bp):121639346End Site(bp):121645325
External Links:
Ensembl ID:ENSG00000248690
Ensembl Transcript ID:N/A
Entrez Gene:594842.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
Glioma  (Score: 0.985791)
Glioma  (Score: 0.985791)
Breast Neoplasms  (Score: 0.731059)
Carcinoma, Ovarian Epithelial  (Score: 0.731059)
Glioblastoma  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Carcinoma, Ovarian Epithelial  (Score: 0.731059)
Glioblastoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D005910
Disease Name:Glioma
Category:MeSH
Type:Neoplasms
Define:Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Alias:Glioma//Gliomas//Glial Cell Tumors//Glial Cell Tumor//Tumor, Glial Cell//Tumors, Glial Cell//Mixed Glioma//Glioma, Mixed//Gliomas, Mixed//Mixed Gliomas//Malignant Glioma//Glioma, Malignant//Gliomas, Malignant//Malignant Gliomas

 

Disease Association Statistics

Total Associated ncRNA Number:660   
More Information
Causal ncRNA Number:606
Network:
Top Causal ncRNAs:
H19  (Score: 1)
H19  (Score: 1)
MEG3  (Score: 1)
UCA1  (Score: 1)
UCA1  (Score: 1)
GAS5  (Score: 1)
FOXD2-AS1  (Score: 1)
NEAT1  (Score: 1)
MEG3  (Score: 1)
PVT1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:ChIP//Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:30790335
Disease Name:Glioma
Sample:glioma tissues
Dysfunction Pattern:Regulation[PI3K/AKT signaling pathway ]
Validated Method:qRT-PCR
Description: In our research, HAS2-AS1 expression was elevated in glioma tissues compared with normal brain tissues. In vitro studies suggested that knocking down HAS2-AS1 expression inhibited glioma cell viability, migration, and invasion through phosphoinositide 3-kinase/protein kinase B signaling pathway.
Causality:Yes
Causal Description:In vitro studies suggested that knocking down HAS2-AS1 expression inhibited glioma cell viability, migration, and invasion through phosphoinositide 3-kinase/protein kinase B signaling pathway.
Clinical-realted Application:. Moreover, high levels of HAS2-AS1 expression was observed in patients with glioma with high WHO grade (III-IV) or large tumor size ( > 4 cm). The survival analysis from The Cancer Genome Atlas showed glioma cases with high HAS2-AS1 expression that had shorter disease-free survival time and overall survival time than those with low HAS2-AS1 expression.

[2] PubMed ID:32776110
Disease Name:Glioma
Sample:glioma tissues and cells
Dysfunction Pattern:regulation[USF1 ]
Validated Method:Western Blot//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//Transwell Assay//ChIP
Description:HAS2-AS1 was highly expressed in glioma tissues and cells, and was significantly associated with poor prognosis.These results suggested that the transcription factor USF1 induced up-regulation of lncRNA HAS2-AS1 and promoted glioma cell invasion and migration.
Causality:Yes
Causal Description:Silencing HAS2-AS1 expression inhibited glioma cell migration, invasion and EMT.
Clinical-realted Application:HAS2-AS1 was highly expressed in glioma tissues and cells, and was significantly associated with poor prognosis.