Entry Detail

General Information

Database ID: LDA0000952
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HAR1A
Full Name:highly accelerated region 1A
Category:LncRNA
Species:Homo sapiens
Synonyms:HAR1F|LINC00064|NCRNA00064
Chromosome:20
Strand:+
Coordinate:
Start Site(bp):63101292End Site(bp):63104386
External Links:
Ensembl ID:ENSG00000225978
Ensembl Transcript ID:N/A
Entrez Gene:768096.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:8   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3908D002289
Disease Name:lung non-small cell carcinomaCarcinoma, Non-Small-Cell Lung
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Alias:NSCLC//Non-small cell lung cancer//non-small cell lung carcinomaCarcinoma, Non-Small-Cell Lung//Carcinoma, Non Small Cell Lung//Carcinomas, Non-Small-Cell Lung//Lung Carcinoma, Non-Small-Cell//Lung Carcinomas, Non-Small-Cell//Non-Small-Cell Lung Carcinomas//Non-Small-Cell Lung Carcinoma//Non Small Cell Lung Carcinoma//Carcinoma, Non-Small Cell Lung//Non-Small Cell Lung Carcinoma//Non-Small Cell Lung Cancer//Nonsmall Cell Lung Cancer

 

Disease Association Statistics

Total Associated ncRNA Number:1090   
More Information
Causal ncRNA Number:936
Network:
Top Causal ncRNAs:
AFAP1-AS1  (Score: 1)
FEZF1-AS1  (Score: 1)
BCYRN1  (Score: 1)
GAS5  (Score: 1)
MALAT1  (Score: 1)
MAGI2-AS3  (Score: 1)
AWPPH  (Score: 1)
DANCR  (Score: 1)
hsa_circ_0007385  (Score: 1)
hsa_circ_0074027  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:35740511
Disease Name:Carcinoma, Non-Small-Cell Lung
Sample:lung adenocarcinoma tissues
Dysfunction Pattern:Regulation(STAT3)
Validated Method:qRT-PCR//Western Blot
Description:We found that lncRNA Highly Accelerated Region 1A (HAR1A) is significantly downregulated in lung adenocarcinoma (LUAD) and negatively associated with prognosis. Additionally, the knockdown of HAR1A accelerated NSCLC cell proliferation but inhibited apoptosis and vice versa. HAR1A regulated cellular activities through the STAT3 signaling pathway. The tumor-suppressing role of HAR1A was verified in the mouse model.
Causality:Yes
Causal Description: Additionally, the knockdown of HAR1A accelerated NSCLC cell proliferation but inhibited apoptosis and vice versa. HAR1A regulated cellular activities through the STAT3 signaling pathway. The tumor-suppressing role of HAR1A was verified in the mouse model.
Clinical-realted Application:We found that lncRNA Highly Accelerated Region 1A (HAR1A) is significantly downregulated in lung adenocarcinoma (LUAD) and negatively associated with prognosis.