Entry Detail

General Information

Database ID: LDA0000980
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HAGLR
Full Name:HOXD antisense growth-associated long non-coding RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXD-AS1|MIR7704HG|Mdgt|STEEL
Chromosome:2
Strand:-
Coordinate:
Start Site(bp):176173189End Site(bp):176188958
External Links:
Ensembl ID:ENSG00000224189
Ensembl Transcript ID:N/A
Entrez Gene:401022.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:38   
More Information
Causal Disease Number:34
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Breast Neoplasms  (Score: 0.731059)
Carcinoma, Ovarian Epithelial  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D013964
Disease Name:Thyroid Neoplasms
Category:MeSH
Type:Neoplasms
Define:Tumors or cancer of the THYROID GLAND.
Alias:Thyroid Neoplasms//Neoplasm, Thyroid//Thyroid Neoplasm//Neoplasms, Thyroid//Thyroid Carcinoma//Carcinoma, Thyroid//Carcinomas, Thyroid//Thyroid Carcinomas//Cancer of Thyroid//Thyroid Cancers//Thyroid Cancer//Cancer, Thyroid//Cancers, Thyroid//Cancer of the Thyroid//Thyroid Adenoma//Adenoma, Thyroid//Adenomas, Thyroid//Thyroid Adenomas

 

Disease Association Statistics

Total Associated ncRNA Number:178   
More Information
Causal ncRNA Number:170
Network:
Top Causal ncRNAs:
hsa_circ_0067934  (Score: 0.999893)
TMC6  (Score: 0.999893)
TMC6  (Score: 0.999893)
hsa_circ_0067934  (Score: 0.999893)
HOTAIRM1  (Score: 0.985791)
H19  (Score: 0.985791)
NORAD  (Score: 0.985791)
PVT1  (Score: 0.985791)
CASC2  (Score: 0.985791)
hsa_circ_0058124  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Transfection//MeRIP//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Cycle Assay//Invasion Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34340128
Disease Name:Thyroid Neoplasms
Sample:TC tumor tissues
Dysfunction Pattern:Expression [highly expressed]
Validated Method:RNA Pull-Down//Western Blot//Transfection//MeRIP//Migration Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Cycle Assay//Invasion Assay
Description:IGF2BP2 was highly expressed in TC tumor tissues. IGF2BP2 knockdown weakened cell proliferative, migratory, and invasive abilities, and induced cell cycle arrest and cell apoptosis in TC cells. LncRNA HAGLR expression was markedly upregulated and positively associated with IGF2BP2 expression in TC tissues. IGF2BP2 knockdown reduced HAGLR expression and transcript stability in TC cells.
Causality:Yes
Causal Description:HAGLR overexpression weakened the effects of IGF2BP2 loss on cell proliferation, migration, invasion, apoptosis, and cell cycle progression in TC cells. HAGLR overexpression weakened the effects of IGF2BP2 loss on cell proliferation, migration, invasion, apoptosis, and cell cycle progression in TC cells.
Clinical-realted Application: