Entry Detail


General Information

Database ID: LDA0000986
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HAGLR
Full Name:HOXD antisense growth-associated long non-coding RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXD-AS1|MIR7704HG|Mdgt|STEEL
Chromosome:2
Strand:-
Coordinate:
Start Site(bp):176173189End Site(bp):176188958
External Links:
Ensembl ID:ENSG00000224189
Ensembl Transcript ID:N/A
Entrez Gene:401022.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:38   
More Information
Causal Disease Number:34
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Breast Neoplasms  (Score: 0.731059)
Carcinoma, Ovarian Epithelial  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10223D003882
Disease Name:dermatomyositisDermatomyositis
Category:Disease OntologyMeSH
Type:Musculoskeletal Diseases
Define:A myositis that results_in inflammation located_in muscle or located_in skin where a skin rash is often seen prior to the onset of muscle weakness. The disease may result from either a viral infection or an autoimmune reaction.A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)
Alias:Polymyositis with skin involvement//dermatopolymyositisDermatomyositis//Dermatopolymyositis//Polymyositis-Dermatomyositis//Polymyositis Dermatomyositis//Dermatomyositis, Adult Type//Adult Type Dermatomyositis//Dermatomyositis, Childhood Type//Childhood Type Dermatomyositis//Juvenile Dermatomyositis//Dermatomyositis, Juvenile//Juvenile Myositis//Myositis, Juvenile

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
HAGLR  (Score: 0.731059)
HAGLR  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//H&E Staining
Weak Evidence:

 

Reference

[1] PubMed ID:35064420
Disease Name:Dermatomyositis
Sample:DM patients
Dysfunction Pattern:Interaction(RUNX3/Foxp3)
Validated Method:In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Luciferase Report Assay//H&E Staining
Description: HAGLR was up-regulated and Foxp3 was down-regulated in DM patients. Besides, RUNX3 protein levels were decreased in DM patients, while its mRNA levels did not change significantly. The proportion of Treg cells was down-regulated in DM patients. In addition, interference with HAGLR could increase the levels of Foxp3, RUNX3 protein level, and the proportion of Treg cells. Besides, there was an interaction between HAGLR and RUNX3. We also found that knockdown of HAGLR and RUNX3 restored the increased Treg cells induced by HAGLR knockdown alone. Interference with HAGLR could increase the protein levels of RUNX3, high levels of RUNX3 further promoted the expression of the Foxp3, thus restoring the number of Treg cells and easing the development of DM.
Causality:Yes
Causal Description:In vivo experiments indicated that injection with adv-HAGLR increased Treg cell proportion and attenuated DM development.
Clinical-realted Application: