Entry Detail

General Information

Database ID: LDA0000988
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:GNAS-AS1
Full Name:GNAS antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:GNAS-AS|GNAS1AS|GNASAS|NCRNA00075|NESP-AS|NESPAS|SANG
Chromosome:20
Strand:-
Coordinate:
Start Site(bp):58818918End Site(bp):58850903
External Links:
Ensembl ID:ENSG00000235590
Ensembl Transcript ID:N/A
Entrez Gene:149775.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:14   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Osteoarthritis  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Nasopharyngeal carcinoma  (Score: 0.731059)
Keloid  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Osteoarthritis  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Nasopharyngeal carcinoma  (Score: 0.731059)
Keloid  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D007627
Disease Name:Keloid
Category:MeSH
Type:Tissues
Define:A sharply elevated, irregularly shaped, progressively enlarging scar resulting from formation of excessive amounts of collagen in the dermis during connective tissue repair. It is differentiated from a hypertrophic scar (CICATRIX, HYPERTROPHIC) in that the former does not spread to surrounding tissues.
Alias:Keloid//Keloids

 

Disease Association Statistics

Total Associated ncRNA Number:14   
More Information
Causal ncRNA Number:14
Network:
Top Causal ncRNAs:
HOXA11-AS  (Score: 0.985791)
H19  (Score: 0.985791)
HOXA11-AS  (Score: 0.985791)
H19  (Score: 0.985791)
GNAS-AS1  (Score: 0.731059)
CACNA1G-AS1  (Score: 0.731059)
hsa_circ_0043688  (Score: 0.731059)
circNRIP1  (Score: 0.731059)
NEAT1  (Score: 0.731059)
GNAS-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:36036334
Disease Name:Keloid
Sample:keloid clinical tissues and HKF cells
Dysfunction Pattern:Interaction( miR-188-5p/RUNX2 axis)
Validated Method:Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay
Description: GNAS-AS1 and RUNX2 expressions were remarkably enhanced, and miR-188-5p expression was decreased in keloid clinical tissues and HKF cells. GNAS-AS1 targeted miR-188-5p to regulate RUNX2 expression. In addition, the inhibition effects of GNAS-AS1 knockdown on HKF cells could be reversed by inhibition of miR-188-5p or overexpression of RUNX2, while RUNX2 overexpression eliminated the suppressive efficaciousness of miR-188-5p mimics on HKF cells growth. GNAS-AS1 knockdown could regulate the miR-188-5p/RUNX2 signaling axis to inhibit the growth and migration in keloid cells.
Causality:Yes
Causal Description:GNAS-AS1 overexpression promoted cells proliferation, migration, and invasion, while GNAS-AS1 knockdown had the opposite trend. Furthermore, overexpression of GNAS-AS1 reversed the inhibitory effect of 5-FU on cell proliferation, migration, and invasion. MiR-188-5p inhibition or RUNX2 overexpression could enhance the proliferation, migration, and invasion of HKF cells.
Clinical-realted Application: