Entry Detail

General Information

Database ID: LDA0001000
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:GAS5
Full Name:growth arrest specific 5
Category:LncRNA
Species:Homo sapiens
Synonyms:NCRNA00030|SNHG2
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):173863899End Site(bp):173868882
External Links:
Ensembl ID:ENSG00000234741
Ensembl Transcript ID:N/A
Entrez Gene:60674.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:128   
More Information
Causal Disease Number:78
Network:
Top Causal Diseases:
Ovarian Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Breast Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Glioma  (Score: 1)
Osteosarcoma  (Score: 1)
Arthritis, Rheumatoid  (Score: 1)
Osteosarcoma  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D007822
Disease Name:Laryngeal Neoplasms
Category:MeSH
Type:Neoplasms
Define:Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.
Alias:Laryngeal Neoplasms//Neoplasms, Laryngeal//Laryngeal Neoplasm//Neoplasm, Laryngeal//Larynx Neoplasms//Larynx Neoplasm//Neoplasm, Larynx//Neoplasms, Larynx//Cancer of Larynx//Larynx Cancers//Laryngeal Cancer//Cancer, Laryngeal//Cancers, Laryngeal//Laryngeal Cancers//Larynx Cancer//Cancer, Larynx//Cancers, Larynx//Cancer of the Larynx

 

Disease Association Statistics

Total Associated ncRNA Number:44   
More Information
Causal ncRNA Number:40
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.985791)
MALAT1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
PCAT19  (Score: 0.731059)
circRANBP9  (Score: 0.731059)
PCAT1  (Score: 0.731059)
SBF2-AS1  (Score: 0.731059)
CYTOR  (Score: 0.731059)
LINC00888  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33641529
Disease Name:Laryngeal Neoplasms
Sample:40 paired laryngeal cancer tissues and adjacent normal tissues
Dysfunction Pattern:Interaction(PI3K/AKT/mTOR Signaling Pathway)
Validated Method:Western Blot//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay//Cell Cycle Assay//Transwell Assay
Description:In the current study, lncRNA GAS5 was downregulated in laryngeal cancer tissues and its low expression was closely associated with poor tumor differentiation, advanced TNM stage, lymph node metastasis, and shorter overall survival time. Mechanistically, our data showed that the overexpression of lncRNA GAS5 significantly regulated the PI3K/AKT/mTOR signaling pathway.
Causality:Yes
Causal Description: In addition, lncRNA GAS5 upregulation significantly inhibited laryngeal cancer cell proliferation both in vitro and in vivo. Moreover, in response to lncRNA GAS5 overexpression, more laryngeal cancer cells were arrested at the G2/M stage, accompanied by increased cell apoptosis rates and suppressed migration and invasion capacities.
Clinical-realted Application:In the current study, lncRNA GAS5 was downregulated in laryngeal cancer tissues and its low expression was closely associated with poor tumor differentiation, advanced TNM stage, lymph node metastasis, and shorter overall survival time.