Entry Detail

General Information

Database ID: LDA0001038
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:GAS5
Full Name:growth arrest specific 5
Category:LncRNA
Species:Homo sapiens
Synonyms:NCRNA00030|SNHG2
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):173863899End Site(bp):173868882
External Links:
Ensembl ID:ENSG00000234741
Ensembl Transcript ID:N/A
Entrez Gene:60674.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:128   
More Information
Causal Disease Number:78
Network:
Top Causal Diseases:
Ovarian Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Breast Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Glioma  (Score: 1)
Osteosarcoma  (Score: 1)
Arthritis, Rheumatoid  (Score: 1)
Osteosarcoma  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:6039C536494
Disease Name:uveal melanomaUveal melanoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A uveal cancer that has_material_basis_in uvea pigment cells.A melanoma that originates from uveal MELANOCYTES and is the most common primary intraocular malignancy. Tumors consist of four cell types: epitheloid, intermediate, mixed, and spindle. Somatic mutations in BAP1, GNAQ, GNA11, EIF1AX, and SF3B1 genes have been identified. OMIM: 155720
Alias:melanoma of Uvea

 

Disease Association Statistics

Total Associated ncRNA Number:14   
More Information
Causal ncRNA Number:14
Network:
Top Causal ncRNAs:
PVT1  (Score: 0.985791)
PVT1  (Score: 0.985791)
GAS5  (Score: 0.731059)
LOC100132707  (Score: 0.731059)
CARD11  (Score: 0.731059)
hsa_circ_0119872  (Score: 0.731059)
SNHG7  (Score: 0.731059)
GAS5  (Score: 0.731059)
LOC100132707  (Score: 0.731059)
CARD11  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33273862
Disease Name:Uveal melanoma
Sample:UM cells and clinical specimens
Dysfunction Pattern:regulation[GAS5/miR-21 axis]
Validated Method:Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay
Description:Our experiments demonstrated that GAS5 was markedly downregulated in UM cells and clinical specimens. Taken together, our findings suggest that GAS5/miR-21 axis is implicated in the pathogenesis of UM and might serve as a potential therapeutic target.
Causality:Yes
Causal Description:Overexpression of GAS5 inhibited, whereas knockdown of GAS5 promoted the viability, migration, and invasion of UM cells.
Clinical-realted Application: