Entry Detail

General Information

Database ID: LDA0001042
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:GAS5
Full Name:growth arrest specific 5
Category:LncRNA
Species:Homo sapiens
Synonyms:NCRNA00030|SNHG2
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):173863899End Site(bp):173868882
External Links:
Ensembl ID:ENSG00000234741
Ensembl Transcript ID:N/A
Entrez Gene:60674.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:128   
More Information
Causal Disease Number:78
Network:
Top Causal Diseases:
Ovarian Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Breast Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Glioma  (Score: 1)
Osteosarcoma  (Score: 1)
Arthritis, Rheumatoid  (Score: 1)
Osteosarcoma  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D018358
Disease Name:Neuroendocrine Tumors
Category:MeSH
Type:Neoplasms
Define:Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.
Alias:Neuroendocrine Tumors//Neuroendocrine Tumor//Tumor, Neuroendocrine//Tumors, Neuroendocrine

 

Disease Association Statistics

Total Associated ncRNA Number:4   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
GAS5  (Score: 0.731059)
GAS5  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35435104
Disease Name:Neuroendocrine Tumors
Sample:PitNET tissues and cells
Dysfunction Pattern:Interaction(miR-27a-5p/cylindromatosis axis)
Validated Method:In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Cycle Assay//Colony Formation Assay
Description: These results suggest that lncRNA GAS5 acts as an endogenous sponge by binding miR-27a-5p to increase the expression of its target gene CYLD, thereby inhibits PitNETs cell proliferation and tumor growth.
Causality:Yes
Causal Description: In vivo lncRNA GAS5 overexpression inhibited GH3 cell tumor growth, while miR-27a-5p mimic or silenced CYLD attenuated the effect of lncRNA GAS5 on GH3 cell tumor growth.
Clinical-realted Application: